Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study

Abstract Background The association of early-life undernutrition and dyslipidemia found in previous studies may be confounded by the uncontrolled age difference between exposed and unexposed participants. The study aimed to investigate the association of early-life undernutrition and the risk of dys...

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Autores principales:	Minmin Wang, Mengfei Liu, Chuanhai Guo, Fenglei Li, Zhen Liu, Yaqi Pan, Fangfang Liu, Ying Liu, Huanyu Bao, Zhe Hu, Hong Cai, Zhonghu He, Yang Ke
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Undernutrition Great Chinese Famine Dyslipidemia Confounding effect Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/b285a123376043e1904c5428e5ecbf29
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spelling	oai:doaj.org-article:b285a123376043e1904c5428e5ecbf292021-11-21T12:11:52ZAssociation of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study10.1186/s12889-021-12211-81471-2458https://doaj.org/article/b285a123376043e1904c5428e5ecbf292021-11-01T00:00:00Zhttps://doi.org/10.1186/s12889-021-12211-8https://doaj.org/toc/1471-2458Abstract Background The association of early-life undernutrition and dyslipidemia found in previous studies may be confounded by the uncontrolled age difference between exposed and unexposed participants. The study aimed to investigate the association of early-life undernutrition and the risk of dyslipidemia in adulthood with good control of the age variable. Methods We took the Great Chinese Famine (1959–1961) as a natural experiment of severe undernutrition. This study was based on the baseline investigation of a population-based cohort in rural China. Undernutrition in early life was defined as being exposed to famine at younger than 3 years of age. Three approaches including Adjustment, Restriction, and Matching were applied to control the confounding effect of age. Logistic regression models were applied to evaluate the association between early-life famine and the presence of dyslipidemia. Stratified analysis by gender was also performed, and potential effect modification was tested by adding the interaction term of the famine exposure variable and gender into the model. Results Undernutrition in early life was associated with increased risk of borderline high and above (BHA) levels of total cholesterol (TC, ORAdjustment = 1.61; ORRestriction = 1.56; ORMatching = 1.87), triglycerides (TG, ORAdjustment = 1.33; ORRestriction = 1.30; ORMatching = 1.34), low-density lipoprotein cholesterol (LDL-C, ORAdjustment = 1.75; ORRestriction = 1.53; ORMatching = 1.77) and dyslipidemia (ORAdjustment = 1.52; ORRestriction = 1.45; ORMatching = 1.60), as well as high levels of TC, TG, LDL-C and dyslipidemia. An inverse association of undernutrition and risk of low high-density lipoprotein cholesterol (HDL-C) was found. Female participants with undernutrition experience had an increased risk of BHA TG and LDL-C (TG: ORAdjustment, female = 1.45; ORRestriction, female = 1.39; ORMatching, female = 1.51; LDL-C: ORAdjustment, female = 2.11; ORRestriction, female = 1.80; ORMatching, female = 2.15), but this association was not found in males. Conclusion Early-life undernutrition increased the risk of TC, TG, LDL-C, and dyslipidemia. Gender would significantly modify this effect for TG and LDL-C. These results emphasize the importance of nutritional conditions in the early stages of life to long-term health consequences.Minmin WangMengfei LiuChuanhai GuoFenglei LiZhen LiuYaqi PanFangfang LiuYing LiuHuanyu BaoZhe HuHong CaiZhonghu HeYang KeBMCarticleUndernutritionGreat Chinese FamineDyslipidemiaConfounding effectPublic aspects of medicineRA1-1270ENBMC Public Health, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Undernutrition Great Chinese Famine Dyslipidemia Confounding effect Public aspects of medicine RA1-1270
spellingShingle	Undernutrition Great Chinese Famine Dyslipidemia Confounding effect Public aspects of medicine RA1-1270 Minmin Wang Mengfei Liu Chuanhai Guo Fenglei Li Zhen Liu Yaqi Pan Fangfang Liu Ying Liu Huanyu Bao Zhe Hu Hong Cai Zhonghu He Yang Ke Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study
description	Abstract Background The association of early-life undernutrition and dyslipidemia found in previous studies may be confounded by the uncontrolled age difference between exposed and unexposed participants. The study aimed to investigate the association of early-life undernutrition and the risk of dyslipidemia in adulthood with good control of the age variable. Methods We took the Great Chinese Famine (1959–1961) as a natural experiment of severe undernutrition. This study was based on the baseline investigation of a population-based cohort in rural China. Undernutrition in early life was defined as being exposed to famine at younger than 3 years of age. Three approaches including Adjustment, Restriction, and Matching were applied to control the confounding effect of age. Logistic regression models were applied to evaluate the association between early-life famine and the presence of dyslipidemia. Stratified analysis by gender was also performed, and potential effect modification was tested by adding the interaction term of the famine exposure variable and gender into the model. Results Undernutrition in early life was associated with increased risk of borderline high and above (BHA) levels of total cholesterol (TC, ORAdjustment = 1.61; ORRestriction = 1.56; ORMatching = 1.87), triglycerides (TG, ORAdjustment = 1.33; ORRestriction = 1.30; ORMatching = 1.34), low-density lipoprotein cholesterol (LDL-C, ORAdjustment = 1.75; ORRestriction = 1.53; ORMatching = 1.77) and dyslipidemia (ORAdjustment = 1.52; ORRestriction = 1.45; ORMatching = 1.60), as well as high levels of TC, TG, LDL-C and dyslipidemia. An inverse association of undernutrition and risk of low high-density lipoprotein cholesterol (HDL-C) was found. Female participants with undernutrition experience had an increased risk of BHA TG and LDL-C (TG: ORAdjustment, female = 1.45; ORRestriction, female = 1.39; ORMatching, female = 1.51; LDL-C: ORAdjustment, female = 2.11; ORRestriction, female = 1.80; ORMatching, female = 2.15), but this association was not found in males. Conclusion Early-life undernutrition increased the risk of TC, TG, LDL-C, and dyslipidemia. Gender would significantly modify this effect for TG and LDL-C. These results emphasize the importance of nutritional conditions in the early stages of life to long-term health consequences.
format	article
author	Minmin Wang Mengfei Liu Chuanhai Guo Fenglei Li Zhen Liu Yaqi Pan Fangfang Liu Ying Liu Huanyu Bao Zhe Hu Hong Cai Zhonghu He Yang Ke
author_facet	Minmin Wang Mengfei Liu Chuanhai Guo Fenglei Li Zhen Liu Yaqi Pan Fangfang Liu Ying Liu Huanyu Bao Zhe Hu Hong Cai Zhonghu He Yang Ke
author_sort	Minmin Wang
title	Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study
title_short	Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study
title_full	Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study
title_fullStr	Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study
title_full_unstemmed	Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study
title_sort	association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b285a123376043e1904c5428e5ecbf29
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Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study

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