GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

GAPDH is generally considered a housekeeping gene and functions in glycolysis. Here, the authors show that GAPDH has a role in promoting vesicle clustering in endosomes and can load siRNA onto the surface of extracellular vesicles, which can be exploited therapeutically.

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Autores principales:	Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir EL Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b286aa9a491c4fbfb8a3ac8161e8f868
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spelling	oai:doaj.org-article:b286aa9a491c4fbfb8a3ac8161e8f8682021-11-21T12:36:16ZGAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain10.1038/s41467-021-27056-32041-1723https://doaj.org/article/b286aa9a491c4fbfb8a3ac8161e8f8682021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27056-3https://doaj.org/toc/2041-1723GAPDH is generally considered a housekeeping gene and functions in glycolysis. Here, the authors show that GAPDH has a role in promoting vesicle clustering in endosomes and can load siRNA onto the surface of extracellular vesicles, which can be exploited therapeutically.Ghulam Hassan DarCláudia C. MendesWei-Li KuanAlfina A. SpecialeMariana ConceiçãoAndré GörgensInna UliyakinaMiguel J. LoboWooi F. LimSamir EL AndaloussiImre MägerThomas C. RobertsRoger A. BarkerDeborah C. I. GoberdhanClive WilsonMatthew J. A. WoodNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ghulam Hassan Dar Cláudia C. Mendes Wei-Li Kuan Alfina A. Speciale Mariana Conceição André Görgens Inna Uliyakina Miguel J. Lobo Wooi F. Lim Samir EL Andaloussi Imre Mäger Thomas C. Roberts Roger A. Barker Deborah C. I. Goberdhan Clive Wilson Matthew J. A. Wood GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
description	GAPDH is generally considered a housekeeping gene and functions in glycolysis. Here, the authors show that GAPDH has a role in promoting vesicle clustering in endosomes and can load siRNA onto the surface of extracellular vesicles, which can be exploited therapeutically.
format	article
author	Ghulam Hassan Dar Cláudia C. Mendes Wei-Li Kuan Alfina A. Speciale Mariana Conceição André Görgens Inna Uliyakina Miguel J. Lobo Wooi F. Lim Samir EL Andaloussi Imre Mäger Thomas C. Roberts Roger A. Barker Deborah C. I. Goberdhan Clive Wilson Matthew J. A. Wood
author_facet	Ghulam Hassan Dar Cláudia C. Mendes Wei-Li Kuan Alfina A. Speciale Mariana Conceição André Görgens Inna Uliyakina Miguel J. Lobo Wooi F. Lim Samir EL Andaloussi Imre Mäger Thomas C. Roberts Roger A. Barker Deborah C. I. Goberdhan Clive Wilson Matthew J. A. Wood
author_sort	Ghulam Hassan Dar
title	GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
title_short	GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
title_full	GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
title_fullStr	GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
title_full_unstemmed	GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain
title_sort	gapdh controls extracellular vesicle biogenesis and enhances the therapeutic potential of ev mediated sirna delivery to the brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b286aa9a491c4fbfb8a3ac8161e8f868
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GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

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