A new nomogram for the prediction of bone metastasis in patients with prostate cancer

Objective This study aimed to establish a new prognostic nomogram for bone metastasis in patients with prostate cancer (PCa). Methods This study retrospectively analyzed clinical data from 332 patients diagnosed with PCa from 2014 to 2019, and patients were randomly divided into a training set (n = ...

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Autores principales:	Gang Bai, Zhonglin Cai, Xiuxia Zhai, Jian Xiong, Fa Zhang, Hongjun Li
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b287a7c709fc4ca7883c8e03603879e8
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id	oai:doaj.org-article:b287a7c709fc4ca7883c8e03603879e8
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spelling	oai:doaj.org-article:b287a7c709fc4ca7883c8e03603879e82021-11-18T01:03:23ZA new nomogram for the prediction of bone metastasis in patients with prostate cancer1473-230010.1177/03000605211058364https://doaj.org/article/b287a7c709fc4ca7883c8e03603879e82021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211058364https://doaj.org/toc/1473-2300Objective This study aimed to establish a new prognostic nomogram for bone metastasis in patients with prostate cancer (PCa). Methods This study retrospectively analyzed clinical data from 332 patients diagnosed with PCa from 2014 to 2019, and patients were randomly divided into a training set (n = 184) and a validation set (n = 148). Multivariate logistic regression analysis was used to establish a prediction model based on the training set, and a nomogram was constructed for visual presentation. The calibration, discrimination and clinical usefulness of the model were evaluated using the validation set. Results Total prostate-specific antigen, clinical tumor stage, Gleason score, prostate volume, red cell distribution width and serum alkaline phosphatase were selected as predictors to develop a prediction model of bone metastasis. After evaluation, the model developed in our study exhibited good discrimination (area under the curve: 0.958; 95% confidence interval: 0.93–0.98), calibration (U = 0.01) and clinical usefulness. Conclusions The new proposed model showed high accuracy for bone metastasis prediction in patients with PCa and good clinical usefulness.Gang BaiZhonglin CaiXiuxia ZhaiJian XiongFa ZhangHongjun LiSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Gang Bai Zhonglin Cai Xiuxia Zhai Jian Xiong Fa Zhang Hongjun Li A new nomogram for the prediction of bone metastasis in patients with prostate cancer
description	Objective This study aimed to establish a new prognostic nomogram for bone metastasis in patients with prostate cancer (PCa). Methods This study retrospectively analyzed clinical data from 332 patients diagnosed with PCa from 2014 to 2019, and patients were randomly divided into a training set (n = 184) and a validation set (n = 148). Multivariate logistic regression analysis was used to establish a prediction model based on the training set, and a nomogram was constructed for visual presentation. The calibration, discrimination and clinical usefulness of the model were evaluated using the validation set. Results Total prostate-specific antigen, clinical tumor stage, Gleason score, prostate volume, red cell distribution width and serum alkaline phosphatase were selected as predictors to develop a prediction model of bone metastasis. After evaluation, the model developed in our study exhibited good discrimination (area under the curve: 0.958; 95% confidence interval: 0.93–0.98), calibration (U = 0.01) and clinical usefulness. Conclusions The new proposed model showed high accuracy for bone metastasis prediction in patients with PCa and good clinical usefulness.
format	article
author	Gang Bai Zhonglin Cai Xiuxia Zhai Jian Xiong Fa Zhang Hongjun Li
author_facet	Gang Bai Zhonglin Cai Xiuxia Zhai Jian Xiong Fa Zhang Hongjun Li
author_sort	Gang Bai
title	A new nomogram for the prediction of bone metastasis in patients with prostate cancer
title_short	A new nomogram for the prediction of bone metastasis in patients with prostate cancer
title_full	A new nomogram for the prediction of bone metastasis in patients with prostate cancer
title_fullStr	A new nomogram for the prediction of bone metastasis in patients with prostate cancer
title_full_unstemmed	A new nomogram for the prediction of bone metastasis in patients with prostate cancer
title_sort	new nomogram for the prediction of bone metastasis in patients with prostate cancer
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/b287a7c709fc4ca7883c8e03603879e8
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A new nomogram for the prediction of bone metastasis in patients with prostate cancer

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