Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

Joshi et al. identify two human metabolites, carnosine and kynurenic acid, that rescue a C. elegans model of Alzheimer’s disease by inhibiting the aggregation of the amyloid beta peptide in vivo. They find that these metabolites trigger a cytosolic unfolded protein response through the transcription...

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Autores principales:	Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M. Dobson, Michele Vendruscolo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b28a52b5717142fcbc1079229aedf157
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spelling	oai:doaj.org-article:b28a52b5717142fcbc1079229aedf1572021-12-02T18:34:12ZTwo human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response10.1038/s42003-021-02218-72399-3642https://doaj.org/article/b28a52b5717142fcbc1079229aedf1572021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02218-7https://doaj.org/toc/2399-3642Joshi et al. identify two human metabolites, carnosine and kynurenic acid, that rescue a C. elegans model of Alzheimer’s disease by inhibiting the aggregation of the amyloid beta peptide in vivo. They find that these metabolites trigger a cytosolic unfolded protein response through the transcription factor HSF-1 and molecular chaperones DNJ-12 and DNJ-19, thus providing mechanistic links between metabolite homeostasis and protein homeostasis to further insights into interventions against neurodegenerative diseases.Priyanka JoshiMichele PerniRyan LimbockerBenedetta ManniniSam CasfordSean ChiaJohnny HabchiJohnathan LabbadiaChristopher M. DobsonMichele VendruscoloNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Priyanka Joshi Michele Perni Ryan Limbocker Benedetta Mannini Sam Casford Sean Chia Johnny Habchi Johnathan Labbadia Christopher M. Dobson Michele Vendruscolo Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
description	Joshi et al. identify two human metabolites, carnosine and kynurenic acid, that rescue a C. elegans model of Alzheimer’s disease by inhibiting the aggregation of the amyloid beta peptide in vivo. They find that these metabolites trigger a cytosolic unfolded protein response through the transcription factor HSF-1 and molecular chaperones DNJ-12 and DNJ-19, thus providing mechanistic links between metabolite homeostasis and protein homeostasis to further insights into interventions against neurodegenerative diseases.
format	article
author	Priyanka Joshi Michele Perni Ryan Limbocker Benedetta Mannini Sam Casford Sean Chia Johnny Habchi Johnathan Labbadia Christopher M. Dobson Michele Vendruscolo
author_facet	Priyanka Joshi Michele Perni Ryan Limbocker Benedetta Mannini Sam Casford Sean Chia Johnny Habchi Johnathan Labbadia Christopher M. Dobson Michele Vendruscolo
author_sort	Priyanka Joshi
title	Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
title_short	Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
title_full	Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
title_fullStr	Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
title_full_unstemmed	Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
title_sort	two human metabolites rescue a c. elegans model of alzheimer’s disease via a cytosolic unfolded protein response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b28a52b5717142fcbc1079229aedf157
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Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

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