Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
Joshi et al. identify two human metabolites, carnosine and kynurenic acid, that rescue a C. elegans model of Alzheimer’s disease by inhibiting the aggregation of the amyloid beta peptide in vivo. They find that these metabolites trigger a cytosolic unfolded protein response through the transcription...
Guardado en:
Autores principales: | Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M. Dobson, Michele Vendruscolo |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/b28a52b5717142fcbc1079229aedf157 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
por: Priyanka Joshi, et al.
Publicado: (2021) -
Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans
por: Michele Perni, et al.
Publicado: (2021) -
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
por: Rodrigo Cataldi, et al.
Publicado: (2021) -
Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
por: Rodrigo Cataldi, et al.
Publicado: (2021) -
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
por: Urszula Nowicka, et al.
Publicado: (2021)