SORLA regulates endosomal trafficking and oncogenic fitness of HER2

The EGF receptor HER2 is an oncogene protein thought to reside at the plasma membrane, but its endosomal trafficking is currently unclear. Here, the authors report that HER2 is endocytosed and that sortillin-related receptor 1 (SORLA) promotes endosomal HER2 recycling and HER2 oncogenic signalling.

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Autores principales:	Mika Pietilä, Pranshu Sahgal, Emilia Peuhu, Niklas Z. Jäntti, Ilkka Paatero, Elisa Närvä, Hussein Al-Akhrass, Johanna Lilja, Maria Georgiadou, Olav M. Andersen, Artur Padzik, Harri Sihto, Heikki Joensuu, Matias Blomqvist, Irena Saarinen, Peter J. Boström, Pekka Taimen, Johanna Ivaska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b28b871b1d0643feb58c297bc60c61de
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spelling	oai:doaj.org-article:b28b871b1d0643feb58c297bc60c61de2021-12-02T16:58:16ZSORLA regulates endosomal trafficking and oncogenic fitness of HER210.1038/s41467-019-10275-02041-1723https://doaj.org/article/b28b871b1d0643feb58c297bc60c61de2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10275-0https://doaj.org/toc/2041-1723The EGF receptor HER2 is an oncogene protein thought to reside at the plasma membrane, but its endosomal trafficking is currently unclear. Here, the authors report that HER2 is endocytosed and that sortillin-related receptor 1 (SORLA) promotes endosomal HER2 recycling and HER2 oncogenic signalling.Mika PietiläPranshu SahgalEmilia PeuhuNiklas Z. JänttiIlkka PaateroElisa NärväHussein Al-AkhrassJohanna LiljaMaria GeorgiadouOlav M. AndersenArtur PadzikHarri SihtoHeikki JoensuuMatias BlomqvistIrena SaarinenPeter J. BoströmPekka TaimenJohanna IvaskaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mika Pietilä Pranshu Sahgal Emilia Peuhu Niklas Z. Jäntti Ilkka Paatero Elisa Närvä Hussein Al-Akhrass Johanna Lilja Maria Georgiadou Olav M. Andersen Artur Padzik Harri Sihto Heikki Joensuu Matias Blomqvist Irena Saarinen Peter J. Boström Pekka Taimen Johanna Ivaska SORLA regulates endosomal trafficking and oncogenic fitness of HER2
description	The EGF receptor HER2 is an oncogene protein thought to reside at the plasma membrane, but its endosomal trafficking is currently unclear. Here, the authors report that HER2 is endocytosed and that sortillin-related receptor 1 (SORLA) promotes endosomal HER2 recycling and HER2 oncogenic signalling.
format	article
author	Mika Pietilä Pranshu Sahgal Emilia Peuhu Niklas Z. Jäntti Ilkka Paatero Elisa Närvä Hussein Al-Akhrass Johanna Lilja Maria Georgiadou Olav M. Andersen Artur Padzik Harri Sihto Heikki Joensuu Matias Blomqvist Irena Saarinen Peter J. Boström Pekka Taimen Johanna Ivaska
author_facet	Mika Pietilä Pranshu Sahgal Emilia Peuhu Niklas Z. Jäntti Ilkka Paatero Elisa Närvä Hussein Al-Akhrass Johanna Lilja Maria Georgiadou Olav M. Andersen Artur Padzik Harri Sihto Heikki Joensuu Matias Blomqvist Irena Saarinen Peter J. Boström Pekka Taimen Johanna Ivaska
author_sort	Mika Pietilä
title	SORLA regulates endosomal trafficking and oncogenic fitness of HER2
title_short	SORLA regulates endosomal trafficking and oncogenic fitness of HER2
title_full	SORLA regulates endosomal trafficking and oncogenic fitness of HER2
title_fullStr	SORLA regulates endosomal trafficking and oncogenic fitness of HER2
title_full_unstemmed	SORLA regulates endosomal trafficking and oncogenic fitness of HER2
title_sort	sorla regulates endosomal trafficking and oncogenic fitness of her2
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b28b871b1d0643feb58c297bc60c61de
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SORLA regulates endosomal trafficking and oncogenic fitness of HER2

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