Vascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma

Background: Juvenile Nasopharyngeal Angiofibroma (JNA) is a benign tumor of mesenchymal tissue, originating from the stromal and blood vessels with dense collagen. However, JNA has a malignant tumor-like property because it can cause erosion of surrounding bone. Vascular Endothelial Growth Factor (V...

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Autores principales:	Ifiq Budiyan Nazar, Yussy Afriani Dewi, Agung Dinasti Permana
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Padjadjaran 2021
Materias:	angiogenesis, juvenile nasopharyngeal angiofibroma, staging, vascular endothelial growth factor Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b28c2e154995478898a95e9cda6e7c19
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spelling	oai:doaj.org-article:b28c2e154995478898a95e9cda6e7c192021-11-17T05:17:31ZVascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma2337-433010.15850/amj.v8n2.2170https://doaj.org/article/b28c2e154995478898a95e9cda6e7c192021-06-01T00:00:00Zhttp://journal.fk.unpad.ac.id/index.php/amj/article/view/2170https://doaj.org/toc/2337-4330Background: Juvenile Nasopharyngeal Angiofibroma (JNA) is a benign tumor of mesenchymal tissue, originating from the stromal and blood vessels with dense collagen. However, JNA has a malignant tumor-like property because it can cause erosion of surrounding bone. Vascular Endothelial Growth Factor (VEGF) plays a role in the angiogenesis process. The expression of VEGF is the best marker to determine the occurrence of angiogenesis in JNA. This study aimed to determine the correlation between VEGF expression and JNA clinical stage. Methods: This was a cross-sectional correlational analytic observational study on medical records and paraffin blocks of all patients with JNA at Dr. Hasan Sadikin General Hospital Bandung during the period of 2016 to 2019. Immunohistochemistry examination of VEGF expressions was performed and VEGF expression was rated based on staining intensity, percentage distribution, and histoscore. Data were then analyzed using the Spearman correlation test. Results: Of 24 patients, 23 males and 1 female, 58% demonstrated a strong intensity of staining. The positivity of VEGF cell percentage was identified as 26–50% (n=6 patients), 51–75% (n=11), and >75% (n=7). The median VEGF histoscores were 2.5, 6.5, and 12 in JNA stage I, stage II, and stage 3, respectively, with the greater VEGF histoscore had a higher clinical stage with a correlation coefficient of (rs) 0.723 (p=0.002). Conclusions: There is a strong correlation between increased VEGF expression and JNA clinical stage. VEGF expression can be used as a prognostic factor of JNA.Ifiq Budiyan NazarYussy Afriani DewiAgung Dinasti PermanaUniversitas Padjadjaranarticleangiogenesis, juvenile nasopharyngeal angiofibroma, staging, vascular endothelial growth factorMedicineRMedicine (General)R5-920ENAlthea Medical Journal, Vol 8, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiogenesis, juvenile nasopharyngeal angiofibroma, staging, vascular endothelial growth factor Medicine R Medicine (General) R5-920
spellingShingle	angiogenesis, juvenile nasopharyngeal angiofibroma, staging, vascular endothelial growth factor Medicine R Medicine (General) R5-920 Ifiq Budiyan Nazar Yussy Afriani Dewi Agung Dinasti Permana Vascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma
description	Background: Juvenile Nasopharyngeal Angiofibroma (JNA) is a benign tumor of mesenchymal tissue, originating from the stromal and blood vessels with dense collagen. However, JNA has a malignant tumor-like property because it can cause erosion of surrounding bone. Vascular Endothelial Growth Factor (VEGF) plays a role in the angiogenesis process. The expression of VEGF is the best marker to determine the occurrence of angiogenesis in JNA. This study aimed to determine the correlation between VEGF expression and JNA clinical stage. Methods: This was a cross-sectional correlational analytic observational study on medical records and paraffin blocks of all patients with JNA at Dr. Hasan Sadikin General Hospital Bandung during the period of 2016 to 2019. Immunohistochemistry examination of VEGF expressions was performed and VEGF expression was rated based on staining intensity, percentage distribution, and histoscore. Data were then analyzed using the Spearman correlation test. Results: Of 24 patients, 23 males and 1 female, 58% demonstrated a strong intensity of staining. The positivity of VEGF cell percentage was identified as 26–50% (n=6 patients), 51–75% (n=11), and >75% (n=7). The median VEGF histoscores were 2.5, 6.5, and 12 in JNA stage I, stage II, and stage 3, respectively, with the greater VEGF histoscore had a higher clinical stage with a correlation coefficient of (rs) 0.723 (p=0.002). Conclusions: There is a strong correlation between increased VEGF expression and JNA clinical stage. VEGF expression can be used as a prognostic factor of JNA.
format	article
author	Ifiq Budiyan Nazar Yussy Afriani Dewi Agung Dinasti Permana
author_facet	Ifiq Budiyan Nazar Yussy Afriani Dewi Agung Dinasti Permana
author_sort	Ifiq Budiyan Nazar
title	Vascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma
title_short	Vascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma
title_full	Vascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma
title_fullStr	Vascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma
title_full_unstemmed	Vascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma
title_sort	vascular endothelial growth factor expression in correlation with stage juvenile nasopharyngeal angiofibroma
publisher	Universitas Padjadjaran
publishDate	2021
url	https://doaj.org/article/b28c2e154995478898a95e9cda6e7c19
work_keys_str_mv	AT ifiqbudiyannazar vascularendothelialgrowthfactorexpressionincorrelationwithstagejuvenilenasopharyngealangiofibroma AT yussyafrianidewi vascularendothelialgrowthfactorexpressionincorrelationwithstagejuvenilenasopharyngealangiofibroma AT agungdinastipermana vascularendothelialgrowthfactorexpressionincorrelationwithstagejuvenilenasopharyngealangiofibroma
_version_	1718425948892692480

Vascular Endothelial Growth Factor Expression in Correlation with Stage Juvenile Nasopharyngeal Angiofibroma

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