Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma

Abstract One of the common mediator of tumour progression is the oxidative stress induced by inflammatory tumour microenvironment (TME). Activated fibroblasts, local and immune cells produce reactive oxygen species (ROS) supporting tumour cell proliferation and pave the way for metastatic tumour gro...

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Autores principales:	Mate Meszaros, Maria Yusenko, Lilla Domonkos, Lehel Peterfi, Gyula Kovacs, Daniel Banyai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b28d1bb711de498388ae1ebf5d071245
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spelling	oai:doaj.org-article:b28d1bb711de498388ae1ebf5d0712452021-12-02T19:02:27ZExpression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma10.1038/s41598-021-96220-y2045-2322https://doaj.org/article/b28d1bb711de498388ae1ebf5d0712452021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96220-yhttps://doaj.org/toc/2045-2322Abstract One of the common mediator of tumour progression is the oxidative stress induced by inflammatory tumour microenvironment (TME). Activated fibroblasts, local and immune cells produce reactive oxygen species (ROS) supporting tumour cell proliferation and pave the way for metastatic tumour growth. TXNIP regulates ROS generation by inhibiting the antioxidative function of thioredoxin (TXN). The shift of TXNIP/TXN balance towards overexpression of TXNIP is associated with proliferation of endothelial cells during tumor angiogenesis. The oxidative stress activates the hypoxia inducible factor-1 (HIF-1), which plays an important role in the biology of conventional RCC (cRCC). Under oxydative stress TXNIP interacts with NLRP3 inflammasome leading to maturation and secretion of inflammatory cytokine IL1β. To establish the role of TXNIP and downstream genes HIF1α and IL1β in the biology of cRCC, we have applied immunohistochemistry to multi-tissue arrays containing tumours of 691 patients without detectable metastases at the time of operation. We found that cRCC displaying a fine organised capillary network with nuclear translocation of TXNIP and expressing IL1β have a good prognosis. In contrary, we showed a significant correlation between cytoplasmic TXNIP expression, inefficient vascularisation by unorganized and tortuous vessels causing tumour cell necrosis and postoperative tumour relapse of cRCC.Mate MeszarosMaria YusenkoLilla DomonkosLehel PeterfiGyula KovacsDaniel BanyaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mate Meszaros Maria Yusenko Lilla Domonkos Lehel Peterfi Gyula Kovacs Daniel Banyai Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma
description	Abstract One of the common mediator of tumour progression is the oxidative stress induced by inflammatory tumour microenvironment (TME). Activated fibroblasts, local and immune cells produce reactive oxygen species (ROS) supporting tumour cell proliferation and pave the way for metastatic tumour growth. TXNIP regulates ROS generation by inhibiting the antioxidative function of thioredoxin (TXN). The shift of TXNIP/TXN balance towards overexpression of TXNIP is associated with proliferation of endothelial cells during tumor angiogenesis. The oxidative stress activates the hypoxia inducible factor-1 (HIF-1), which plays an important role in the biology of conventional RCC (cRCC). Under oxydative stress TXNIP interacts with NLRP3 inflammasome leading to maturation and secretion of inflammatory cytokine IL1β. To establish the role of TXNIP and downstream genes HIF1α and IL1β in the biology of cRCC, we have applied immunohistochemistry to multi-tissue arrays containing tumours of 691 patients without detectable metastases at the time of operation. We found that cRCC displaying a fine organised capillary network with nuclear translocation of TXNIP and expressing IL1β have a good prognosis. In contrary, we showed a significant correlation between cytoplasmic TXNIP expression, inefficient vascularisation by unorganized and tortuous vessels causing tumour cell necrosis and postoperative tumour relapse of cRCC.
format	article
author	Mate Meszaros Maria Yusenko Lilla Domonkos Lehel Peterfi Gyula Kovacs Daniel Banyai
author_facet	Mate Meszaros Maria Yusenko Lilla Domonkos Lehel Peterfi Gyula Kovacs Daniel Banyai
author_sort	Mate Meszaros
title	Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma
title_short	Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma
title_full	Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma
title_fullStr	Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma
title_full_unstemmed	Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma
title_sort	expression of txnip is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b28d1bb711de498388ae1ebf5d071245
work_keys_str_mv	AT matemeszaros expressionoftxnipisassociatedwithangiogenesisandpostoperativerelapseofconventionalrenalcellcarcinoma AT mariayusenko expressionoftxnipisassociatedwithangiogenesisandpostoperativerelapseofconventionalrenalcellcarcinoma AT lilladomonkos expressionoftxnipisassociatedwithangiogenesisandpostoperativerelapseofconventionalrenalcellcarcinoma AT lehelpeterfi expressionoftxnipisassociatedwithangiogenesisandpostoperativerelapseofconventionalrenalcellcarcinoma AT gyulakovacs expressionoftxnipisassociatedwithangiogenesisandpostoperativerelapseofconventionalrenalcellcarcinoma AT danielbanyai expressionoftxnipisassociatedwithangiogenesisandpostoperativerelapseofconventionalrenalcellcarcinoma
_version_	1718377289399402496

Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma

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