Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome

Excision of internal transcribed spacer 2 (ITS2) within eukaryotic pre-ribosomal RNA is essential for ribosome function. Here, the authors reconstitute the entire cycle of ITS2 processing in vitro using purified components, providing insights into the cleavage process and demonstrating that 26S pre-...

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Autores principales:	Lisa Fromm, Sebastian Falk, Dirk Flemming, Jan Michael Schuller, Matthias Thoms, Elena Conti, Ed Hurt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b28d8e98866847018326ad389cebdf76
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spelling	oai:doaj.org-article:b28d8e98866847018326ad389cebdf762021-12-02T14:42:20ZReconstitution of the complete pathway of ITS2 processing at the pre-ribosome10.1038/s41467-017-01786-92041-1723https://doaj.org/article/b28d8e98866847018326ad389cebdf762017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01786-9https://doaj.org/toc/2041-1723Excision of internal transcribed spacer 2 (ITS2) within eukaryotic pre-ribosomal RNA is essential for ribosome function. Here, the authors reconstitute the entire cycle of ITS2 processing in vitro using purified components, providing insights into the cleavage process and demonstrating that 26S pre-rRNA processing necessarily precedes 7S pre-rRNA processing.Lisa FrommSebastian FalkDirk FlemmingJan Michael SchullerMatthias ThomsElena ContiEd HurtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lisa Fromm Sebastian Falk Dirk Flemming Jan Michael Schuller Matthias Thoms Elena Conti Ed Hurt Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome
description	Excision of internal transcribed spacer 2 (ITS2) within eukaryotic pre-ribosomal RNA is essential for ribosome function. Here, the authors reconstitute the entire cycle of ITS2 processing in vitro using purified components, providing insights into the cleavage process and demonstrating that 26S pre-rRNA processing necessarily precedes 7S pre-rRNA processing.
format	article
author	Lisa Fromm Sebastian Falk Dirk Flemming Jan Michael Schuller Matthias Thoms Elena Conti Ed Hurt
author_facet	Lisa Fromm Sebastian Falk Dirk Flemming Jan Michael Schuller Matthias Thoms Elena Conti Ed Hurt
author_sort	Lisa Fromm
title	Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome
title_short	Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome
title_full	Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome
title_fullStr	Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome
title_full_unstemmed	Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome
title_sort	reconstitution of the complete pathway of its2 processing at the pre-ribosome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b28d8e98866847018326ad389cebdf76
work_keys_str_mv	AT lisafromm reconstitutionofthecompletepathwayofits2processingatthepreribosome AT sebastianfalk reconstitutionofthecompletepathwayofits2processingatthepreribosome AT dirkflemming reconstitutionofthecompletepathwayofits2processingatthepreribosome AT janmichaelschuller reconstitutionofthecompletepathwayofits2processingatthepreribosome AT matthiasthoms reconstitutionofthecompletepathwayofits2processingatthepreribosome AT elenaconti reconstitutionofthecompletepathwayofits2processingatthepreribosome AT edhurt reconstitutionofthecompletepathwayofits2processingatthepreribosome
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Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome

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