Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.

Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolaemia associated with CCl4-induced hepatic injury in rats without improving liver function in our previous study. This present study investigated the lipid lo...

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Autores principales:	Martins Ekor, Phyllis Elsie Owusu Agyei, Ernest Obese, Robert Peter Biney, Isaac Tabiri Henneh, Meshack Antwi-Adjei, Ewura Seidu Yahaya, Gordon Amoakohene, Patrick Kafui Akakpo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b28e6cd8d910428ab561d668c2da7962
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spelling	oai:doaj.org-article:b28e6cd8d910428ab561d668c2da79622021-12-02T20:15:00ZCelecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.1932-620310.1371/journal.pone.0247735https://doaj.org/article/b28e6cd8d910428ab561d668c2da79622021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0247735https://doaj.org/toc/1932-6203Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolaemia associated with CCl4-induced hepatic injury in rats without improving liver function in our previous study. This present study investigated the lipid lowering potential of celecoxib in normal rats fed with coconut oil subjected to five deep-frying episodes. Male Sprague Dawley rats were randomly assigned to groups (n = 6 rats/group) which received physiological saline (10 mL/kg), unheated coconut oil (UO, 10 mL/kg) or heated coconut oil (HO, 10 ml/kg) for 60 days. Groups that received HO were subsequently treated with either physiological saline, atorvastatin (25 mg/kg), celecoxib (5 mg/kg) or celecoxib (10 mg/kg) in the last fifteen days of the experiment. Rats were sacrificed 24 hours after last treatment and blood and tissue samples collected for analysis. HO consumption produced significant hyperlipidaemia and elevation in marker enzymes of hepatic function. Celecoxib ameliorated the hyperlipidaemia as shown by the significantly (P<0.05) lower total cholesterol, triglycerides, low and very low density lipoprotein in the celecoxib-treated rats when compared with HO-fed rats that received saline. Celecoxib also reduced (P<0.05) alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and liver weight of hyperlipidaemic rats. Similarly, hepatocellular damage with the hyperlipidaemia was significantly reversed by celecoxib. However, serum TNF-α and IL-6 did not change significantly between the various groups. Taken together, data from this study suggest that celecoxib may exert therapeutic benefit in hyperlipidaemia and its attendant consequences.Martins EkorPhyllis Elsie Owusu AgyeiErnest ObeseRobert Peter BineyIsaac Tabiri HennehMeshack Antwi-AdjeiEwura Seidu YahayaGordon AmoakohenePatrick Kafui AkakpoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0247735 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martins Ekor Phyllis Elsie Owusu Agyei Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Meshack Antwi-Adjei Ewura Seidu Yahaya Gordon Amoakohene Patrick Kafui Akakpo Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.
description	Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolaemia associated with CCl4-induced hepatic injury in rats without improving liver function in our previous study. This present study investigated the lipid lowering potential of celecoxib in normal rats fed with coconut oil subjected to five deep-frying episodes. Male Sprague Dawley rats were randomly assigned to groups (n = 6 rats/group) which received physiological saline (10 mL/kg), unheated coconut oil (UO, 10 mL/kg) or heated coconut oil (HO, 10 ml/kg) for 60 days. Groups that received HO were subsequently treated with either physiological saline, atorvastatin (25 mg/kg), celecoxib (5 mg/kg) or celecoxib (10 mg/kg) in the last fifteen days of the experiment. Rats were sacrificed 24 hours after last treatment and blood and tissue samples collected for analysis. HO consumption produced significant hyperlipidaemia and elevation in marker enzymes of hepatic function. Celecoxib ameliorated the hyperlipidaemia as shown by the significantly (P<0.05) lower total cholesterol, triglycerides, low and very low density lipoprotein in the celecoxib-treated rats when compared with HO-fed rats that received saline. Celecoxib also reduced (P<0.05) alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and liver weight of hyperlipidaemic rats. Similarly, hepatocellular damage with the hyperlipidaemia was significantly reversed by celecoxib. However, serum TNF-α and IL-6 did not change significantly between the various groups. Taken together, data from this study suggest that celecoxib may exert therapeutic benefit in hyperlipidaemia and its attendant consequences.
format	article
author	Martins Ekor Phyllis Elsie Owusu Agyei Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Meshack Antwi-Adjei Ewura Seidu Yahaya Gordon Amoakohene Patrick Kafui Akakpo
author_facet	Martins Ekor Phyllis Elsie Owusu Agyei Ernest Obese Robert Peter Biney Isaac Tabiri Henneh Meshack Antwi-Adjei Ewura Seidu Yahaya Gordon Amoakohene Patrick Kafui Akakpo
author_sort	Martins Ekor
title	Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.
title_short	Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.
title_full	Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.
title_fullStr	Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.
title_full_unstemmed	Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.
title_sort	celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b28e6cd8d910428ab561d668c2da7962
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Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.

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