Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital

Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital

Hideaki Yokogawa, Akira Kobayashi, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: To report surgical therapies for corneal perforations in a tertiary referral hospital.Methods: Thirty...

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Autores principales: Yokogawa H, Kobayashi A, Yamazaki N, Masaki T, Sugiyama K
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Lenguaje:EN
Publicado: Dove Medical Press 2014
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/b28f7e10abc749f4be8236605a362d69
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spelling oai:doaj.org-article:b28f7e10abc749f4be8236605a362d692021-12-02T05:40:24ZSurgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital1177-5483https://doaj.org/article/b28f7e10abc749f4be8236605a362d692014-10-01T00:00:00Zhttp://www.dovepress.com/surgical-therapies-for-corneal-perforations-10nbspyears-of-cases-in-a--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Hideaki Yokogawa, Akira Kobayashi, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: To report surgical therapies for corneal perforations in a tertiary referral hospital.Methods: Thirty-one eyes of 31 patients (aged 62.4±18.3 years) with surgically treated corneal perforations from January 2002 to July 2013 were included in this study. Demographic data such as cause of corneal perforation, surgical procedures, and visual outcomes were retrospectively analyzed.Results: The causes of corneal perforation (n=31) were divided into infectious (n=8, 26%) and noninfectious (n=23, 74%) categories. Infectious causes included fungal ulcer, herpetic stromal necrotizing keratitis, and bacterial ulcer. The causes of noninfectious keratopathy included corneal melting after removal of a metal foreign body, severe dry eye, lagophthalmos, canaliculitis, the oral anticancer drug S-1, keratoconus, rheumatoid arthritis, neurotrophic ulcer, atopic keratoconjunctivitis, and unknown causes. Initial surgical procedures included central large corneal graft (n=17), small corneal graft (n=7), and amniotic membrane transplantation (n=7). In two cases the perforation could not be sealed during the first surgical treatment and required subsequent procedures. All infectious keratitis required central large penetrating keratoplasty to obtain anatomical cure. In contrast, several surgical options were used for the treatment of noninfectious keratitis. After surgical treatment, anatomical cure was obtained in all cases. Mean postoperative best corrected visual acuity was better at 6 months (logMAR 1.3) than preoperatively (logMAR 1.8).Conclusion: Surgical therapies for corneal perforations in our hospital included central large lamellar/penetrating keratoplasty, small peripheral patch graft, and amniotic membrane transplantation. All treatments were effective. Corneal perforation due to the oral anticancer drug S-1 is newly reported. Keywords: corneal perforation, keratoplasty, amniotic membrane transplantationYokogawa HKobayashi AYamazaki NMasaki TSugiyama KDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2165-2170 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Yokogawa H
Kobayashi A
Yamazaki N
Masaki T
Sugiyama K
Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital
description Hideaki Yokogawa, Akira Kobayashi, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanPurpose: To report surgical therapies for corneal perforations in a tertiary referral hospital.Methods: Thirty-one eyes of 31 patients (aged 62.4±18.3 years) with surgically treated corneal perforations from January 2002 to July 2013 were included in this study. Demographic data such as cause of corneal perforation, surgical procedures, and visual outcomes were retrospectively analyzed.Results: The causes of corneal perforation (n=31) were divided into infectious (n=8, 26%) and noninfectious (n=23, 74%) categories. Infectious causes included fungal ulcer, herpetic stromal necrotizing keratitis, and bacterial ulcer. The causes of noninfectious keratopathy included corneal melting after removal of a metal foreign body, severe dry eye, lagophthalmos, canaliculitis, the oral anticancer drug S-1, keratoconus, rheumatoid arthritis, neurotrophic ulcer, atopic keratoconjunctivitis, and unknown causes. Initial surgical procedures included central large corneal graft (n=17), small corneal graft (n=7), and amniotic membrane transplantation (n=7). In two cases the perforation could not be sealed during the first surgical treatment and required subsequent procedures. All infectious keratitis required central large penetrating keratoplasty to obtain anatomical cure. In contrast, several surgical options were used for the treatment of noninfectious keratitis. After surgical treatment, anatomical cure was obtained in all cases. Mean postoperative best corrected visual acuity was better at 6 months (logMAR 1.3) than preoperatively (logMAR 1.8).Conclusion: Surgical therapies for corneal perforations in our hospital included central large lamellar/penetrating keratoplasty, small peripheral patch graft, and amniotic membrane transplantation. All treatments were effective. Corneal perforation due to the oral anticancer drug S-1 is newly reported. Keywords: corneal perforation, keratoplasty, amniotic membrane transplantation
format article
author Yokogawa H
Kobayashi A
Yamazaki N
Masaki T
Sugiyama K
author_facet Yokogawa H
Kobayashi A
Yamazaki N
Masaki T
Sugiyama K
author_sort Yokogawa H
title Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital
title_short Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital
title_full Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital
title_fullStr Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital
title_full_unstemmed Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital
title_sort surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/b28f7e10abc749f4be8236605a362d69
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