(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages

Abstract Cystic fibrosis (CF) is characterized by chronic bacterial infections and heightened inflammation. Widespread ineffective antibiotic use has led to increased isolation of drug resistant bacterial strains from respiratory samples. (R)-roscovitine (Seliciclib) is a unique drug that has many b...

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Autores principales: Chandra L. Shrestha, Shuzhong Zhang, Benjamin Wisniewski, Stephanie Häfner, Jonathan Elie, Laurent Meijer, Benjamin T. Kopp
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b28faafa018e4d7a8701559c160e0ad9
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