Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.

Circadian clocks provide an internal measure of external time allowing organisms to anticipate and exploit predictable daily changes in the environment. Rhythms driven by circadian clocks have a temperature compensated periodicity of approximately 24 hours that persists in constant conditions and ca...

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Autores principales:	Yu-Yao Tseng, Suzanne M Hunt, Christian Heintzen, Susan K Crosthwaite, Jean-Marc Schwartz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b290983104b54c388ff650c4a8bb86d9
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spelling	oai:doaj.org-article:b290983104b54c388ff650c4a8bb86d92021-11-18T05:51:27ZComprehensive modelling of the Neurospora circadian clock and its temperature compensation.1553-734X1553-735810.1371/journal.pcbi.1002437https://doaj.org/article/b290983104b54c388ff650c4a8bb86d92012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22496627/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Circadian clocks provide an internal measure of external time allowing organisms to anticipate and exploit predictable daily changes in the environment. Rhythms driven by circadian clocks have a temperature compensated periodicity of approximately 24 hours that persists in constant conditions and can be reset by environmental time cues. Computational modelling has aided our understanding of the molecular mechanisms of circadian clocks, nevertheless it remains a major challenge to integrate the large number of clock components and their interactions into a single, comprehensive model that is able to account for the full breadth of clock phenotypes. Here we present a comprehensive dynamic model of the Neurospora crassa circadian clock that incorporates its key components and their transcriptional and post-transcriptional regulation. The model accounts for a wide range of clock characteristics including: a periodicity of 21.6 hours, persistent oscillation in constant conditions, arrhythmicity in constant light, resetting by brief light pulses, and entrainment to full photoperiods. Crucial components influencing the period and amplitude of oscillations were identified by control analysis. Furthermore, simulations enabled us to propose a mechanism for temperature compensation, which is achieved by simultaneously increasing the translation of frq RNA and decreasing the nuclear import of FRQ protein.Yu-Yao TsengSuzanne M HuntChristian HeintzenSusan K CrosthwaiteJean-Marc SchwartzPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 3, p e1002437 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yu-Yao Tseng Suzanne M Hunt Christian Heintzen Susan K Crosthwaite Jean-Marc Schwartz Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.
description	Circadian clocks provide an internal measure of external time allowing organisms to anticipate and exploit predictable daily changes in the environment. Rhythms driven by circadian clocks have a temperature compensated periodicity of approximately 24 hours that persists in constant conditions and can be reset by environmental time cues. Computational modelling has aided our understanding of the molecular mechanisms of circadian clocks, nevertheless it remains a major challenge to integrate the large number of clock components and their interactions into a single, comprehensive model that is able to account for the full breadth of clock phenotypes. Here we present a comprehensive dynamic model of the Neurospora crassa circadian clock that incorporates its key components and their transcriptional and post-transcriptional regulation. The model accounts for a wide range of clock characteristics including: a periodicity of 21.6 hours, persistent oscillation in constant conditions, arrhythmicity in constant light, resetting by brief light pulses, and entrainment to full photoperiods. Crucial components influencing the period and amplitude of oscillations were identified by control analysis. Furthermore, simulations enabled us to propose a mechanism for temperature compensation, which is achieved by simultaneously increasing the translation of frq RNA and decreasing the nuclear import of FRQ protein.
format	article
author	Yu-Yao Tseng Suzanne M Hunt Christian Heintzen Susan K Crosthwaite Jean-Marc Schwartz
author_facet	Yu-Yao Tseng Suzanne M Hunt Christian Heintzen Susan K Crosthwaite Jean-Marc Schwartz
author_sort	Yu-Yao Tseng
title	Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.
title_short	Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.
title_full	Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.
title_fullStr	Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.
title_full_unstemmed	Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.
title_sort	comprehensive modelling of the neurospora circadian clock and its temperature compensation.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b290983104b54c388ff650c4a8bb86d9
work_keys_str_mv	AT yuyaotseng comprehensivemodellingoftheneurosporacircadianclockanditstemperaturecompensation AT suzannemhunt comprehensivemodellingoftheneurosporacircadianclockanditstemperaturecompensation AT christianheintzen comprehensivemodellingoftheneurosporacircadianclockanditstemperaturecompensation AT susankcrosthwaite comprehensivemodellingoftheneurosporacircadianclockanditstemperaturecompensation AT jeanmarcschwartz comprehensivemodellingoftheneurosporacircadianclockanditstemperaturecompensation
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Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.

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