Effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice
Mulberry possesses many biological characteristics, such as reduce blood sugar and antioxidant properties, but whether mulberry galacto-oligosaccharide (MGO) can impact the characteristics of the gut microbiota is not yet clear. The objective of this work was to investigate the protective effects of...
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2021
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oai:doaj.org-article:b292bcb95f8f4e55b131eb89c4732c612021-11-10T04:21:52ZEffect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice1756-464610.1016/j.jff.2021.104836https://doaj.org/article/b292bcb95f8f4e55b131eb89c4732c612021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621004850https://doaj.org/toc/1756-4646Mulberry possesses many biological characteristics, such as reduce blood sugar and antioxidant properties, but whether mulberry galacto-oligosaccharide (MGO) can impact the characteristics of the gut microbiota is not yet clear. The objective of this work was to investigate the protective effects of MGO in type 2 diabetic (T2D) mice. The analysis of typical diabetic symptoms and serum status showed that oral MGO alleviated hyperglycemia, insulin resistance and oxidative stress in diabetic mice. These changes were caused by up-regulating the expression of key proteins in the PI3K/Akt pathway, involved in the control of liver glycolysis and gluconeogenesis, and liver glucose metabolism having a positive hypoglycemic effect. Additionally, the gut microbiota indicated that MGO treatment could positively modulate the microbiome composition to decrease the blood glucose in diabetic mice by promoting the growth of Prevotellaceae and Lactobacillus, whereas decreasing the abundance of Lachnospiraceae.Erna LiXiaoshan LongSentai LiaoDaorui PangQian LiYuxiao ZouElsevierarticleType 2 diabeticMulberry galacto-oligosaccharideGut microbiotaNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104836- (2021) |
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Type 2 diabetic Mulberry galacto-oligosaccharide Gut microbiota Nutrition. Foods and food supply TX341-641 |
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Type 2 diabetic Mulberry galacto-oligosaccharide Gut microbiota Nutrition. Foods and food supply TX341-641 Erna Li Xiaoshan Long Sentai Liao Daorui Pang Qian Li Yuxiao Zou Effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice |
| description |
Mulberry possesses many biological characteristics, such as reduce blood sugar and antioxidant properties, but whether mulberry galacto-oligosaccharide (MGO) can impact the characteristics of the gut microbiota is not yet clear. The objective of this work was to investigate the protective effects of MGO in type 2 diabetic (T2D) mice. The analysis of typical diabetic symptoms and serum status showed that oral MGO alleviated hyperglycemia, insulin resistance and oxidative stress in diabetic mice. These changes were caused by up-regulating the expression of key proteins in the PI3K/Akt pathway, involved in the control of liver glycolysis and gluconeogenesis, and liver glucose metabolism having a positive hypoglycemic effect. Additionally, the gut microbiota indicated that MGO treatment could positively modulate the microbiome composition to decrease the blood glucose in diabetic mice by promoting the growth of Prevotellaceae and Lactobacillus, whereas decreasing the abundance of Lachnospiraceae. |
| format |
article |
| author |
Erna Li Xiaoshan Long Sentai Liao Daorui Pang Qian Li Yuxiao Zou |
| author_facet |
Erna Li Xiaoshan Long Sentai Liao Daorui Pang Qian Li Yuxiao Zou |
| author_sort |
Erna Li |
| title |
Effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice |
| title_short |
Effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice |
| title_full |
Effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice |
| title_fullStr |
Effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice |
| title_full_unstemmed |
Effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice |
| title_sort |
effect of mulberry galacto-oligosaccharide isolated from mulberry on glucose metabolism and gut microbiota in a type 2 diabetic mice |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/b292bcb95f8f4e55b131eb89c4732c61 |
| work_keys_str_mv |
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