A dynamical role for acetylcholine in synaptic renormalization.

Although sleep is a fundamental behavior observed in virtually all animal species, its functions remain unclear. One leading proposal, known as the synaptic renormalization hypothesis, suggests that sleep is necessary to counteract a global strengthening of synapses that occurs during wakefulness. E...

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Autores principales:	Christian G Fink, Geoffrey G Murphy, Michal Zochowski, Victoria Booth
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b29346107dbf40e4b413c3ebf98ee506
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id	oai:doaj.org-article:b29346107dbf40e4b413c3ebf98ee506
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spelling	oai:doaj.org-article:b29346107dbf40e4b413c3ebf98ee5062021-11-18T05:52:21ZA dynamical role for acetylcholine in synaptic renormalization.1553-734X1553-735810.1371/journal.pcbi.1002939https://doaj.org/article/b29346107dbf40e4b413c3ebf98ee5062013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23516342/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Although sleep is a fundamental behavior observed in virtually all animal species, its functions remain unclear. One leading proposal, known as the synaptic renormalization hypothesis, suggests that sleep is necessary to counteract a global strengthening of synapses that occurs during wakefulness. Evidence for sleep-dependent synaptic downscaling (or synaptic renormalization) has been observed experimentally, but the physiological mechanisms which generate this phenomenon are unknown. In this study, we propose that changes in neuronal membrane excitability induced by acetylcholine may provide a dynamical mechanism for both wake-dependent synaptic upscaling and sleep-dependent downscaling. We show in silico that cholinergically-induced changes in network firing patterns alter overall network synaptic potentiation when synaptic strengths evolve through spike-timing dependent plasticity mechanisms. Specifically, network synaptic potentiation increases dramatically with high cholinergic concentration and decreases dramatically with low levels of acetylcholine. We demonstrate that this phenomenon is robust across variation of many different network parameters.Christian G FinkGeoffrey G MurphyMichal ZochowskiVictoria BoothPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 3, p e1002939 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Christian G Fink Geoffrey G Murphy Michal Zochowski Victoria Booth A dynamical role for acetylcholine in synaptic renormalization.
description	Although sleep is a fundamental behavior observed in virtually all animal species, its functions remain unclear. One leading proposal, known as the synaptic renormalization hypothesis, suggests that sleep is necessary to counteract a global strengthening of synapses that occurs during wakefulness. Evidence for sleep-dependent synaptic downscaling (or synaptic renormalization) has been observed experimentally, but the physiological mechanisms which generate this phenomenon are unknown. In this study, we propose that changes in neuronal membrane excitability induced by acetylcholine may provide a dynamical mechanism for both wake-dependent synaptic upscaling and sleep-dependent downscaling. We show in silico that cholinergically-induced changes in network firing patterns alter overall network synaptic potentiation when synaptic strengths evolve through spike-timing dependent plasticity mechanisms. Specifically, network synaptic potentiation increases dramatically with high cholinergic concentration and decreases dramatically with low levels of acetylcholine. We demonstrate that this phenomenon is robust across variation of many different network parameters.
format	article
author	Christian G Fink Geoffrey G Murphy Michal Zochowski Victoria Booth
author_facet	Christian G Fink Geoffrey G Murphy Michal Zochowski Victoria Booth
author_sort	Christian G Fink
title	A dynamical role for acetylcholine in synaptic renormalization.
title_short	A dynamical role for acetylcholine in synaptic renormalization.
title_full	A dynamical role for acetylcholine in synaptic renormalization.
title_fullStr	A dynamical role for acetylcholine in synaptic renormalization.
title_full_unstemmed	A dynamical role for acetylcholine in synaptic renormalization.
title_sort	dynamical role for acetylcholine in synaptic renormalization.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b29346107dbf40e4b413c3ebf98ee506
work_keys_str_mv	AT christiangfink adynamicalroleforacetylcholineinsynapticrenormalization AT geoffreygmurphy adynamicalroleforacetylcholineinsynapticrenormalization AT michalzochowski adynamicalroleforacetylcholineinsynapticrenormalization AT victoriabooth adynamicalroleforacetylcholineinsynapticrenormalization AT christiangfink dynamicalroleforacetylcholineinsynapticrenormalization AT geoffreygmurphy dynamicalroleforacetylcholineinsynapticrenormalization AT michalzochowski dynamicalroleforacetylcholineinsynapticrenormalization AT victoriabooth dynamicalroleforacetylcholineinsynapticrenormalization
_version_	1718424750093500416

A dynamical role for acetylcholine in synaptic renormalization.

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