Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites

Identifying kinases responsible for specific phosphorylation events remains challenging. Here, the authors leverage kinase inhibitor profiles for the identification of kinase-substrate site pairs in cell extracts, developing a method that can identify the enzymes responsible for unassigned phosphory...

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Autores principales:	Nikolaus A. Watson, Tyrell N. Cartwright, Conor Lawless, Marcos Cámara-Donoso, Onur Sen, Kosuke Sako, Toru Hirota, Hiroshi Kimura, Jonathan M. G. Higgins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b294ddbbf60f47f4a39a93619abb8a39
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spelling	oai:doaj.org-article:b294ddbbf60f47f4a39a93619abb8a392021-12-02T15:39:17ZKinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites10.1038/s41467-020-15428-02041-1723https://doaj.org/article/b294ddbbf60f47f4a39a93619abb8a392020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15428-0https://doaj.org/toc/2041-1723Identifying kinases responsible for specific phosphorylation events remains challenging. Here, the authors leverage kinase inhibitor profiles for the identification of kinase-substrate site pairs in cell extracts, developing a method that can identify the enzymes responsible for unassigned phosphorylation events.Nikolaus A. WatsonTyrell N. CartwrightConor LawlessMarcos Cámara-DonosoOnur SenKosuke SakoToru HirotaHiroshi KimuraJonathan M. G. HigginsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolaus A. Watson Tyrell N. Cartwright Conor Lawless Marcos Cámara-Donoso Onur Sen Kosuke Sako Toru Hirota Hiroshi Kimura Jonathan M. G. Higgins Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites
description	Identifying kinases responsible for specific phosphorylation events remains challenging. Here, the authors leverage kinase inhibitor profiles for the identification of kinase-substrate site pairs in cell extracts, developing a method that can identify the enzymes responsible for unassigned phosphorylation events.
format	article
author	Nikolaus A. Watson Tyrell N. Cartwright Conor Lawless Marcos Cámara-Donoso Onur Sen Kosuke Sako Toru Hirota Hiroshi Kimura Jonathan M. G. Higgins
author_facet	Nikolaus A. Watson Tyrell N. Cartwright Conor Lawless Marcos Cámara-Donoso Onur Sen Kosuke Sako Toru Hirota Hiroshi Kimura Jonathan M. G. Higgins
author_sort	Nikolaus A. Watson
title	Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites
title_short	Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites
title_full	Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites
title_fullStr	Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites
title_full_unstemmed	Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites
title_sort	kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b294ddbbf60f47f4a39a93619abb8a39
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Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites

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