Decreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles
BackgroundWhether female BMI impacts the DNA repair ability in the oocytes after fertilization has not been investigated. The aim of this study is to assess the early embryo quality and reproductive outcomes of oocytes from overweight women when fertilized with sperm with varying degrees of DNA frag...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:b29605bfaa344980949032c0fb02bf692021-11-30T12:59:21ZDecreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles1664-239210.3389/fendo.2021.756336https://doaj.org/article/b29605bfaa344980949032c0fb02bf692021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.756336/fullhttps://doaj.org/toc/1664-2392BackgroundWhether female BMI impacts the DNA repair ability in the oocytes after fertilization has not been investigated. The aim of this study is to assess the early embryo quality and reproductive outcomes of oocytes from overweight women when fertilized with sperm with varying degrees of DNA fragmentation.MethodsA total number of 1,612 patients undergoing fresh autologous in vitro fertilization (IVF) cycles was included. These patients were divided into two groups according to maternal body mass index (BMI): normal weight group (18.5–24.9 kg/m2; n=1187; 73.64%) and overweight group (≥25 kg/m2; n=425; 26.36%). Each group was then subdivided into two groups by sperm DNA fragmentation index (DFI): low fragmentation group (<20% DFI, LF) and high fragmentation group (≥20% DFI, HF). Laboratory and clinical outcomes were compared between subgroups.ResultsFor the normal-weight group, there was no statistical significance in embryo quality and reproductive outcomes between the LF and HF groups. But in the overweight group, significantly lower fertilization rate (LF: 64%; HF: 59%; p=0.011), blastocyst development rate (LF: 57%; HF: 44%; p=0.001), as well as high-quality blastocyst rate (LF: 32%; HF: 22%; p=0.034) were found in the HF group, despite the similar pregnancy rates (LF: 56%; HF: 60%; p=0.630).ConclusionsDecreased DNA repair activity in oocytes may be a possible mechanism for the low early development potential of embryos from overweight patients in in vitro fertilization cycles.Hui LiHui LiHui LiHuan WangHuan WangHuan WangJing ZhuJing ZhuJing ZhuJianmin XuJianmin XuJianmin XuYuqing JiangYuqing JiangYuqing JiangWenhui ChenWenhui ChenWenhui ChenYingpu SunYingpu SunYingpu SunQingling YangQingling YangQingling YangFrontiers Media S.A.articleobesityoocyteembryo qualitysperm DNA fragmentation (SDF)DNA repairin vitro fertilizationDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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obesity oocyte embryo quality sperm DNA fragmentation (SDF) DNA repair in vitro fertilization Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
obesity oocyte embryo quality sperm DNA fragmentation (SDF) DNA repair in vitro fertilization Diseases of the endocrine glands. Clinical endocrinology RC648-665 Hui Li Hui Li Hui Li Huan Wang Huan Wang Huan Wang Jing Zhu Jing Zhu Jing Zhu Jianmin Xu Jianmin Xu Jianmin Xu Yuqing Jiang Yuqing Jiang Yuqing Jiang Wenhui Chen Wenhui Chen Wenhui Chen Yingpu Sun Yingpu Sun Yingpu Sun Qingling Yang Qingling Yang Qingling Yang Decreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles |
| description |
BackgroundWhether female BMI impacts the DNA repair ability in the oocytes after fertilization has not been investigated. The aim of this study is to assess the early embryo quality and reproductive outcomes of oocytes from overweight women when fertilized with sperm with varying degrees of DNA fragmentation.MethodsA total number of 1,612 patients undergoing fresh autologous in vitro fertilization (IVF) cycles was included. These patients were divided into two groups according to maternal body mass index (BMI): normal weight group (18.5–24.9 kg/m2; n=1187; 73.64%) and overweight group (≥25 kg/m2; n=425; 26.36%). Each group was then subdivided into two groups by sperm DNA fragmentation index (DFI): low fragmentation group (<20% DFI, LF) and high fragmentation group (≥20% DFI, HF). Laboratory and clinical outcomes were compared between subgroups.ResultsFor the normal-weight group, there was no statistical significance in embryo quality and reproductive outcomes between the LF and HF groups. But in the overweight group, significantly lower fertilization rate (LF: 64%; HF: 59%; p=0.011), blastocyst development rate (LF: 57%; HF: 44%; p=0.001), as well as high-quality blastocyst rate (LF: 32%; HF: 22%; p=0.034) were found in the HF group, despite the similar pregnancy rates (LF: 56%; HF: 60%; p=0.630).ConclusionsDecreased DNA repair activity in oocytes may be a possible mechanism for the low early development potential of embryos from overweight patients in in vitro fertilization cycles. |
| format |
article |
| author |
Hui Li Hui Li Hui Li Huan Wang Huan Wang Huan Wang Jing Zhu Jing Zhu Jing Zhu Jianmin Xu Jianmin Xu Jianmin Xu Yuqing Jiang Yuqing Jiang Yuqing Jiang Wenhui Chen Wenhui Chen Wenhui Chen Yingpu Sun Yingpu Sun Yingpu Sun Qingling Yang Qingling Yang Qingling Yang |
| author_facet |
Hui Li Hui Li Hui Li Huan Wang Huan Wang Huan Wang Jing Zhu Jing Zhu Jing Zhu Jianmin Xu Jianmin Xu Jianmin Xu Yuqing Jiang Yuqing Jiang Yuqing Jiang Wenhui Chen Wenhui Chen Wenhui Chen Yingpu Sun Yingpu Sun Yingpu Sun Qingling Yang Qingling Yang Qingling Yang |
| author_sort |
Hui Li |
| title |
Decreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles |
| title_short |
Decreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles |
| title_full |
Decreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles |
| title_fullStr |
Decreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles |
| title_full_unstemmed |
Decreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles |
| title_sort |
decreased dna repair ability: a mechanism for low early embryonic development potential of oocytes from overweight patients after fertilization in ivf cycles |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/b29605bfaa344980949032c0fb02bf69 |
| work_keys_str_mv |
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