Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
Summary: The mammalian target of rapamycin (mTOR) is a serine-threonine kinase involved in cellular innate immunity, metabolism, and senescence. FK506-binding protein 12 (FKBP12) inhibits mTOR kinase activity via direct association. The FKBP12-mTOR association can be strengthened by the immunosuppre...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
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Elsevier
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/b2965a81e40b4d1b8790ed81223de156 |
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