Model-based analysis uncovers mutations altering autophagy selectivity in human cancer

Although autophagy has been linked to tumourigenesis, it is unclear how genomic alterations affect autophagy selectivity in tumours. Here, the authors establish a pipeline that integrates computational and experimental approaches to show that altered autophagy selectivity is frequent in cancer cells...

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Autores principales:	Zhu Han, Weizhi Zhang, Wanshan Ning, Chenwei Wang, Wankun Deng, Zhidan Li, Zehua Shang, Xiaofei Shen, Xiaohui Liu, Otto Baba, Tsuyoshi Morita, Lu Chen, Yu Xue, Da Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b297a2c17e62427299d5a53ccf1dcfaa
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spelling	oai:doaj.org-article:b297a2c17e62427299d5a53ccf1dcfaa2021-12-02T15:56:54ZModel-based analysis uncovers mutations altering autophagy selectivity in human cancer10.1038/s41467-021-23539-52041-1723https://doaj.org/article/b297a2c17e62427299d5a53ccf1dcfaa2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23539-5https://doaj.org/toc/2041-1723Although autophagy has been linked to tumourigenesis, it is unclear how genomic alterations affect autophagy selectivity in tumours. Here, the authors establish a pipeline that integrates computational and experimental approaches to show that altered autophagy selectivity is frequent in cancer cells and link glycogen autophagy with tumourigenesis.Zhu HanWeizhi ZhangWanshan NingChenwei WangWankun DengZhidan LiZehua ShangXiaofei ShenXiaohui LiuOtto BabaTsuyoshi MoritaLu ChenYu XueDa JiaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhu Han Weizhi Zhang Wanshan Ning Chenwei Wang Wankun Deng Zhidan Li Zehua Shang Xiaofei Shen Xiaohui Liu Otto Baba Tsuyoshi Morita Lu Chen Yu Xue Da Jia Model-based analysis uncovers mutations altering autophagy selectivity in human cancer
description	Although autophagy has been linked to tumourigenesis, it is unclear how genomic alterations affect autophagy selectivity in tumours. Here, the authors establish a pipeline that integrates computational and experimental approaches to show that altered autophagy selectivity is frequent in cancer cells and link glycogen autophagy with tumourigenesis.
format	article
author	Zhu Han Weizhi Zhang Wanshan Ning Chenwei Wang Wankun Deng Zhidan Li Zehua Shang Xiaofei Shen Xiaohui Liu Otto Baba Tsuyoshi Morita Lu Chen Yu Xue Da Jia
author_facet	Zhu Han Weizhi Zhang Wanshan Ning Chenwei Wang Wankun Deng Zhidan Li Zehua Shang Xiaofei Shen Xiaohui Liu Otto Baba Tsuyoshi Morita Lu Chen Yu Xue Da Jia
author_sort	Zhu Han
title	Model-based analysis uncovers mutations altering autophagy selectivity in human cancer
title_short	Model-based analysis uncovers mutations altering autophagy selectivity in human cancer
title_full	Model-based analysis uncovers mutations altering autophagy selectivity in human cancer
title_fullStr	Model-based analysis uncovers mutations altering autophagy selectivity in human cancer
title_full_unstemmed	Model-based analysis uncovers mutations altering autophagy selectivity in human cancer
title_sort	model-based analysis uncovers mutations altering autophagy selectivity in human cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b297a2c17e62427299d5a53ccf1dcfaa
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Model-based analysis uncovers mutations altering autophagy selectivity in human cancer

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