Model-based analysis uncovers mutations altering autophagy selectivity in human cancer

Although autophagy has been linked to tumourigenesis, it is unclear how genomic alterations affect autophagy selectivity in tumours. Here, the authors establish a pipeline that integrates computational and experimental approaches to show that altered autophagy selectivity is frequent in cancer cells...

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Bibliographic Details
Main Authors: Zhu Han, Weizhi Zhang, Wanshan Ning, Chenwei Wang, Wankun Deng, Zhidan Li, Zehua Shang, Xiaofei Shen, Xiaohui Liu, Otto Baba, Tsuyoshi Morita, Lu Chen, Yu Xue, Da Jia
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/b297a2c17e62427299d5a53ccf1dcfaa
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