Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities

Abstract. Daba GM, Elkhateeb WA, El-Dien AN, Ahmed EF, El Hagrassi AM Fayad W, Wen TC. 2020. Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities. Biodiversitas 21: 2437-2445. Evaluating in v...

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Autores principales:	ghoson Daba, Waill Elkhateeb, Asmaa Negm ELDien, Eman Fadl, Ali Elhagrasi, Walid Fayad, Ting Chi Wen
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2020
Materias:	anti-colon cancer; antioxidant; dictyophora indusiata; hericium erinaceus, hypocholesterolemic; metacordyceps neogunnii Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b29a42d8e5a343c6b67bf807b6f27d97
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spelling	oai:doaj.org-article:b29a42d8e5a343c6b67bf807b6f27d972021-11-22T00:40:46ZTherapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities1412-033X2085-472210.13057/biodiv/d210615https://doaj.org/article/b29a42d8e5a343c6b67bf807b6f27d972020-05-01T00:00:00Zhttps://smujo.id/biodiv/article/view/5934https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Daba GM, Elkhateeb WA, El-Dien AN, Ahmed EF, El Hagrassi AM Fayad W, Wen TC. 2020. Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities. Biodiversitas 21: 2437-2445. Evaluating in vitro biological activities of the medicinal mushrooms Hericium erinaceus, Metacordyceps neogunnii, and Dictyophora indusiata n-hexane extracts revealed their capabilities as promising therapeutic sources. By assessing their DPPH radical scavenging activities, D. indusiata extract exhibited the highest antioxidant activity (87.8±1.2%) followed by H. erinaceus, then M. neogunnii 84.9±1.6%, and 77.3±1.3%, respectively. On the other hand, M. neogunnii extract exerted promising anti-colon cancer (68.6±3.6% cytotoxicity) against HCT116 human colon cancer cell lines at concentration 100 ?g/mL, whereas H. erinaceus and D. indusiata extracts exhibited weaker cytotoxic effects (18.3±1.7%, and 19.3±3.2%, respectively) using the same concentration. Investigating cholesterol reduction activities (CRA%) of the extracts revealed that activity depends on both extract concentration and incubation period. After 96 h of incubation at room temperature, all extracts exerted potent in vitro hypocholesterolemic activities (100±0% reduction in cholesterol concentration). Performing GC-Ms analyses on the extracts revealed presence of 22 compounds in D. indusiata extract, while 29 compounds were detected in M. neogunnii extract, and 33 in H. erinaceus extract. Most of compounds were esters of fatty acids. Results in this study encourage using these mushrooms as functional foods, and highlight the need for conducting further in vivo studies to support their use in pharmaceutical industry.ghoson DabaWaill ElkhateebAsmaa Negm ELDienEman FadlAli ElhagrasiWalid FayadTing Chi WenMBI & UNS Soloarticleanti-colon cancer; antioxidant; dictyophora indusiata; hericium erinaceus, hypocholesterolemic; metacordyceps neogunniiBiology (General)QH301-705.5ENBiodiversitas, Vol 21, Iss 6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-colon cancer; antioxidant; dictyophora indusiata; hericium erinaceus, hypocholesterolemic; metacordyceps neogunnii Biology (General) QH301-705.5
spellingShingle	anti-colon cancer; antioxidant; dictyophora indusiata; hericium erinaceus, hypocholesterolemic; metacordyceps neogunnii Biology (General) QH301-705.5 ghoson Daba Waill Elkhateeb Asmaa Negm ELDien Eman Fadl Ali Elhagrasi Walid Fayad Ting Chi Wen Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities
description	Abstract. Daba GM, Elkhateeb WA, El-Dien AN, Ahmed EF, El Hagrassi AM Fayad W, Wen TC. 2020. Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities. Biodiversitas 21: 2437-2445. Evaluating in vitro biological activities of the medicinal mushrooms Hericium erinaceus, Metacordyceps neogunnii, and Dictyophora indusiata n-hexane extracts revealed their capabilities as promising therapeutic sources. By assessing their DPPH radical scavenging activities, D. indusiata extract exhibited the highest antioxidant activity (87.8±1.2%) followed by H. erinaceus, then M. neogunnii 84.9±1.6%, and 77.3±1.3%, respectively. On the other hand, M. neogunnii extract exerted promising anti-colon cancer (68.6±3.6% cytotoxicity) against HCT116 human colon cancer cell lines at concentration 100 ?g/mL, whereas H. erinaceus and D. indusiata extracts exhibited weaker cytotoxic effects (18.3±1.7%, and 19.3±3.2%, respectively) using the same concentration. Investigating cholesterol reduction activities (CRA%) of the extracts revealed that activity depends on both extract concentration and incubation period. After 96 h of incubation at room temperature, all extracts exerted potent in vitro hypocholesterolemic activities (100±0% reduction in cholesterol concentration). Performing GC-Ms analyses on the extracts revealed presence of 22 compounds in D. indusiata extract, while 29 compounds were detected in M. neogunnii extract, and 33 in H. erinaceus extract. Most of compounds were esters of fatty acids. Results in this study encourage using these mushrooms as functional foods, and highlight the need for conducting further in vivo studies to support their use in pharmaceutical industry.
format	article
author	ghoson Daba Waill Elkhateeb Asmaa Negm ELDien Eman Fadl Ali Elhagrasi Walid Fayad Ting Chi Wen
author_facet	ghoson Daba Waill Elkhateeb Asmaa Negm ELDien Eman Fadl Ali Elhagrasi Walid Fayad Ting Chi Wen
author_sort	ghoson Daba
title	Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities
title_short	Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities
title_full	Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities
title_fullStr	Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities
title_full_unstemmed	Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities
title_sort	therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities
publisher	MBI & UNS Solo
publishDate	2020
url	https://doaj.org/article/b29a42d8e5a343c6b67bf807b6f27d97
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Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities

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