Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α

Paralogs HIF1α and HIF2α are important modulators regulating cellular transcriptional profile following hypoxia. Here, the authors investigate evolutionary substitutions that fine tune the interaction between HIFα and their regulator VHL in the vertebrate and invertebrate lineages.

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Detalles Bibliográficos
Autores principales:	Daniel Tarade, Jeffrey E. Lee, Michael Ohh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b29e1bfc93264b549d65fd4ba12bd03a
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spelling	oai:doaj.org-article:b29e1bfc93264b549d65fd4ba12bd03a2021-12-02T16:50:57ZEvolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α10.1038/s41467-019-11149-12041-1723https://doaj.org/article/b29e1bfc93264b549d65fd4ba12bd03a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11149-1https://doaj.org/toc/2041-1723Paralogs HIF1α and HIF2α are important modulators regulating cellular transcriptional profile following hypoxia. Here, the authors investigate evolutionary substitutions that fine tune the interaction between HIFα and their regulator VHL in the vertebrate and invertebrate lineages.Daniel TaradeJeffrey E. LeeMichael OhhNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Tarade Jeffrey E. Lee Michael Ohh Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
description	Paralogs HIF1α and HIF2α are important modulators regulating cellular transcriptional profile following hypoxia. Here, the authors investigate evolutionary substitutions that fine tune the interaction between HIFα and their regulator VHL in the vertebrate and invertebrate lineages.
format	article
author	Daniel Tarade Jeffrey E. Lee Michael Ohh
author_facet	Daniel Tarade Jeffrey E. Lee Michael Ohh
author_sort	Daniel Tarade
title	Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
title_short	Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
title_full	Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
title_fullStr	Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
title_full_unstemmed	Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
title_sort	evolution of metazoan oxygen-sensing involved a conserved divergence of vhl affinity for hif1α and hif2α
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b29e1bfc93264b549d65fd4ba12bd03a
work_keys_str_mv	AT danieltarade evolutionofmetazoanoxygensensinginvolvedaconserveddivergenceofvhlaffinityforhif1aandhif2a AT jeffreyelee evolutionofmetazoanoxygensensinginvolvedaconserveddivergenceofvhlaffinityforhif1aandhif2a AT michaelohh evolutionofmetazoanoxygensensinginvolvedaconserveddivergenceofvhlaffinityforhif1aandhif2a
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Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α

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