Epidemiology of Kaposi’s Sarcoma

Kaposi’s sarcoma is an angioproliferative tumor caused by human herpesvirus 8 in the context of immunodeficiency, such as that induced by HIV infection or immunosuppressive therapy. Its incidence has dramatically fallen in patients living with HIV (PLHIV) since the introduction of potent antiretrovi...

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Autores principales:	Sophie Grabar, Dominique Costagliola
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Kaposi’s sarcoma cancer epidemiology human herpesvirus 8 KSHV HIV infection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b2a294aebf554fc193e46c2a9b6be0e0
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spelling	oai:doaj.org-article:b2a294aebf554fc193e46c2a9b6be0e02021-11-25T17:02:42ZEpidemiology of Kaposi’s Sarcoma10.3390/cancers132256922072-6694https://doaj.org/article/b2a294aebf554fc193e46c2a9b6be0e02021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5692https://doaj.org/toc/2072-6694Kaposi’s sarcoma is an angioproliferative tumor caused by human herpesvirus 8 in the context of immunodeficiency, such as that induced by HIV infection or immunosuppressive therapy. Its incidence has dramatically fallen in patients living with HIV (PLHIV) since the introduction of potent antiretroviral combinations 25 years ago due to the restoration of immunity and better control of HIV replication. However, KS is still one of the most frequently occurring cancers in PLHIV, in particular in men who have sex with men and in sub-Saharan Africa, where it is still endemic. Even in the context of restored immunity, the risk of KS is still more than 30 times higher in PLHIV than in the general population. Recent evidence indicates that early initiation of antiretroviral treatment, which is recommended by current guidelines, may reduce the risk of KS but it needs to be accompanied by early access to care. This review mainly focuses on the recent epidemiological features of KS in the context of HIV infection.Sophie GrabarDominique CostagliolaMDPI AGarticleKaposi’s sarcomacancerepidemiologyhuman herpesvirus 8KSHVHIV infectionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5692, p 5692 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Kaposi’s sarcoma cancer epidemiology human herpesvirus 8 KSHV HIV infection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Kaposi’s sarcoma cancer epidemiology human herpesvirus 8 KSHV HIV infection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sophie Grabar Dominique Costagliola Epidemiology of Kaposi’s Sarcoma
description	Kaposi’s sarcoma is an angioproliferative tumor caused by human herpesvirus 8 in the context of immunodeficiency, such as that induced by HIV infection or immunosuppressive therapy. Its incidence has dramatically fallen in patients living with HIV (PLHIV) since the introduction of potent antiretroviral combinations 25 years ago due to the restoration of immunity and better control of HIV replication. However, KS is still one of the most frequently occurring cancers in PLHIV, in particular in men who have sex with men and in sub-Saharan Africa, where it is still endemic. Even in the context of restored immunity, the risk of KS is still more than 30 times higher in PLHIV than in the general population. Recent evidence indicates that early initiation of antiretroviral treatment, which is recommended by current guidelines, may reduce the risk of KS but it needs to be accompanied by early access to care. This review mainly focuses on the recent epidemiological features of KS in the context of HIV infection.
format	article
author	Sophie Grabar Dominique Costagliola
author_facet	Sophie Grabar Dominique Costagliola
author_sort	Sophie Grabar
title	Epidemiology of Kaposi’s Sarcoma
title_short	Epidemiology of Kaposi’s Sarcoma
title_full	Epidemiology of Kaposi’s Sarcoma
title_fullStr	Epidemiology of Kaposi’s Sarcoma
title_full_unstemmed	Epidemiology of Kaposi’s Sarcoma
title_sort	epidemiology of kaposi’s sarcoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b2a294aebf554fc193e46c2a9b6be0e0
work_keys_str_mv	AT sophiegrabar epidemiologyofkaposissarcoma AT dominiquecostagliola epidemiologyofkaposissarcoma
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Epidemiology of Kaposi’s Sarcoma

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