The Sox2 transcription factor binds RNA

Some transcription factors have been proposed to functionally interact with RNA to facilitate proper regulation of gene expression. Here the authors demonstrate that human Sox2 interact directly and with high affinity to RNAs through its HMG DNA-binding domain.

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Autores principales:	Zachariah E. Holmes, Desmond J. Hamilton, Taeyoung Hwang, Nicholas V. Parsonnet, John L. Rinn, Deborah S. Wuttke, Robert T. Batey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b2a71949f809466bb1ecf7371b1026f2
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spelling	oai:doaj.org-article:b2a71949f809466bb1ecf7371b1026f22021-12-02T17:06:32ZThe Sox2 transcription factor binds RNA10.1038/s41467-020-15571-82041-1723https://doaj.org/article/b2a71949f809466bb1ecf7371b1026f22020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15571-8https://doaj.org/toc/2041-1723Some transcription factors have been proposed to functionally interact with RNA to facilitate proper regulation of gene expression. Here the authors demonstrate that human Sox2 interact directly and with high affinity to RNAs through its HMG DNA-binding domain.Zachariah E. HolmesDesmond J. HamiltonTaeyoung HwangNicholas V. ParsonnetJohn L. RinnDeborah S. WuttkeRobert T. BateyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zachariah E. Holmes Desmond J. Hamilton Taeyoung Hwang Nicholas V. Parsonnet John L. Rinn Deborah S. Wuttke Robert T. Batey The Sox2 transcription factor binds RNA
description	Some transcription factors have been proposed to functionally interact with RNA to facilitate proper regulation of gene expression. Here the authors demonstrate that human Sox2 interact directly and with high affinity to RNAs through its HMG DNA-binding domain.
format	article
author	Zachariah E. Holmes Desmond J. Hamilton Taeyoung Hwang Nicholas V. Parsonnet John L. Rinn Deborah S. Wuttke Robert T. Batey
author_facet	Zachariah E. Holmes Desmond J. Hamilton Taeyoung Hwang Nicholas V. Parsonnet John L. Rinn Deborah S. Wuttke Robert T. Batey
author_sort	Zachariah E. Holmes
title	The Sox2 transcription factor binds RNA
title_short	The Sox2 transcription factor binds RNA
title_full	The Sox2 transcription factor binds RNA
title_fullStr	The Sox2 transcription factor binds RNA
title_full_unstemmed	The Sox2 transcription factor binds RNA
title_sort	sox2 transcription factor binds rna
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b2a71949f809466bb1ecf7371b1026f2
work_keys_str_mv	AT zachariaheholmes thesox2transcriptionfactorbindsrna AT desmondjhamilton thesox2transcriptionfactorbindsrna AT taeyounghwang thesox2transcriptionfactorbindsrna AT nicholasvparsonnet thesox2transcriptionfactorbindsrna AT johnlrinn thesox2transcriptionfactorbindsrna AT deborahswuttke thesox2transcriptionfactorbindsrna AT roberttbatey thesox2transcriptionfactorbindsrna AT zachariaheholmes sox2transcriptionfactorbindsrna AT desmondjhamilton sox2transcriptionfactorbindsrna AT taeyounghwang sox2transcriptionfactorbindsrna AT nicholasvparsonnet sox2transcriptionfactorbindsrna AT johnlrinn sox2transcriptionfactorbindsrna AT deborahswuttke sox2transcriptionfactorbindsrna AT roberttbatey sox2transcriptionfactorbindsrna
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The Sox2 transcription factor binds RNA

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