Comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China

Abstract To examine the association between various retinal vascular measurements and microalbuminuria in patients with type 2 diabetes in a northwestern China study. Data from 911 patients with type 2 diabetes were analyzed. Novel retinal vascular measurements from the whole vascular tree were extr...

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Autores principales:	Xiayu Xu, Fei Sun, Qiong Wang, Maiye Zhang, Wenxiang Ding, Aili Yang, Bin Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b2ab2f1436cb4bf7a652f2d8f75bc071
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spelling	oai:doaj.org-article:b2ab2f1436cb4bf7a652f2d8f75bc0712021-12-02T18:50:57ZComprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China10.1038/s41598-020-70408-02045-2322https://doaj.org/article/b2ab2f1436cb4bf7a652f2d8f75bc0712020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70408-0https://doaj.org/toc/2045-2322Abstract To examine the association between various retinal vascular measurements and microalbuminuria in patients with type 2 diabetes in a northwestern China study. Data from 911 patients with type 2 diabetes were analyzed. Novel retinal vascular measurements from the whole vascular tree were extracted using a validated fully automatic computer program. Retinal vascular measurements were analyzed continuously and categorically for associations with microalbuminuria using multiple logistic regressions, adjusted for related variables. In logistic regression adjusting for multiple variables, microalbuminuria was associated with smaller peripheral arteriolar caliber, larger peripheral venular caliber, larger arteriolar tortuosity, and smaller arteriolar fractal dimension (p = 0.028, p < 0.001, p = 0.038, p = 0.035, respectively). In further categorical analyses, microalbuminuria was related to smaller peripheral arteriolar caliber [T1 vs. T3: odds ratio (OR) 2.029; 95% confidence interval (CI) 1.186–3.473], larger peripheral venular caliber (T1 vs. T3: OR 0.609; 95% CI 0.362–1.024), and smaller arteriolar fractal dimension (T1 vs. T3: OR 1.659; 95% CI 1.028–2.675). Microalbuminuria in type 2 diabetes is associated with both retinal vascular caliber and geometry. These noninvasive vascular measurements serve as potential preclinical markers to identify populations at high risk of early kidney disease in the course of diabetes.Xiayu XuFei SunQiong WangMaiye ZhangWenxiang DingAili YangBin GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiayu Xu Fei Sun Qiong Wang Maiye Zhang Wenxiang Ding Aili Yang Bin Gao Comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China
description	Abstract To examine the association between various retinal vascular measurements and microalbuminuria in patients with type 2 diabetes in a northwestern China study. Data from 911 patients with type 2 diabetes were analyzed. Novel retinal vascular measurements from the whole vascular tree were extracted using a validated fully automatic computer program. Retinal vascular measurements were analyzed continuously and categorically for associations with microalbuminuria using multiple logistic regressions, adjusted for related variables. In logistic regression adjusting for multiple variables, microalbuminuria was associated with smaller peripheral arteriolar caliber, larger peripheral venular caliber, larger arteriolar tortuosity, and smaller arteriolar fractal dimension (p = 0.028, p < 0.001, p = 0.038, p = 0.035, respectively). In further categorical analyses, microalbuminuria was related to smaller peripheral arteriolar caliber [T1 vs. T3: odds ratio (OR) 2.029; 95% confidence interval (CI) 1.186–3.473], larger peripheral venular caliber (T1 vs. T3: OR 0.609; 95% CI 0.362–1.024), and smaller arteriolar fractal dimension (T1 vs. T3: OR 1.659; 95% CI 1.028–2.675). Microalbuminuria in type 2 diabetes is associated with both retinal vascular caliber and geometry. These noninvasive vascular measurements serve as potential preclinical markers to identify populations at high risk of early kidney disease in the course of diabetes.
format	article
author	Xiayu Xu Fei Sun Qiong Wang Maiye Zhang Wenxiang Ding Aili Yang Bin Gao
author_facet	Xiayu Xu Fei Sun Qiong Wang Maiye Zhang Wenxiang Ding Aili Yang Bin Gao
author_sort	Xiayu Xu
title	Comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China
title_short	Comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China
title_full	Comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China
title_fullStr	Comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China
title_full_unstemmed	Comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China
title_sort	comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in china
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b2ab2f1436cb4bf7a652f2d8f75bc071
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Comprehensive retinal vascular measurements: a novel association with renal function in type 2 diabetic patients in China

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