Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner

Abstract A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet b...

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Autores principales:	David P. Cormode, Salim Si-Mohamed, Daniel Bar-Ness, Monica Sigovan, Pratap C. Naha, Joelle Balegamire, Franck Lavenne, Philippe Coulon, Ewald Roessl, Matthias Bartels, Michal Rokni, Ira Blevis, Loic Boussel, Philippe Douek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b2ae545bf47442cdb66177ce98cd2d81
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spelling	oai:doaj.org-article:b2ae545bf47442cdb66177ce98cd2d812021-12-02T16:06:20ZMulticolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner10.1038/s41598-017-04659-92045-2322https://doaj.org/article/b2ae545bf47442cdb66177ce98cd2d812017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04659-9https://doaj.org/toc/2045-2322Abstract A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents’ concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo.David P. CormodeSalim Si-MohamedDaniel Bar-NessMonica SigovanPratap C. NahaJoelle BalegamireFranck LavennePhilippe CoulonEwald RoesslMatthias BartelsMichal RokniIra BlevisLoic BousselPhilippe DouekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David P. Cormode Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Pratap C. Naha Joelle Balegamire Franck Lavenne Philippe Coulon Ewald Roessl Matthias Bartels Michal Rokni Ira Blevis Loic Boussel Philippe Douek Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
description	Abstract A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents’ concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo.
format	article
author	David P. Cormode Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Pratap C. Naha Joelle Balegamire Franck Lavenne Philippe Coulon Ewald Roessl Matthias Bartels Michal Rokni Ira Blevis Loic Boussel Philippe Douek
author_facet	David P. Cormode Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Pratap C. Naha Joelle Balegamire Franck Lavenne Philippe Coulon Ewald Roessl Matthias Bartels Michal Rokni Ira Blevis Loic Boussel Philippe Douek
author_sort	David P. Cormode
title	Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
title_short	Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
title_full	Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
title_fullStr	Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
title_full_unstemmed	Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
title_sort	multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b2ae545bf47442cdb66177ce98cd2d81
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Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner

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