Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
Fasciolosis is a parasitic disease that causes economic losses. In the present study, the protective effects of silymarin alone and in combination with clorsulon were investigated in sheep naturally infected with Fasciola hepatica. For this purpose, 40 Sangsari breed sheep were used, which were...
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| Format: | article |
| Langue: | FA |
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Islamic Azad University, Tabriz Branch
2021
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| Accès en ligne: | https://doaj.org/article/b2af70f801dd4196bff7cfc61fdae874 |
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| Résumé: | Fasciolosis is a parasitic disease that causes economic losses. In the present study, the protective effects of silymarin alone and in combination with clorsulon were investigated in sheep naturally infected with Fasciola hepatica. For this purpose, 40 Sangsari breed sheep were used, which were divided into five groups, including 1- healthy sheep without treatment 2- fasciolosis affected sheep without treatment 3- fasciolosis affected sheep treated with silymarin 4- fasciolosis affected sheep treated with Clorsulon, and 5- fasciolosis affected sheep treated with silymarin and clorsulon. Biochemical parameters including triglyceride, total bilirubin, total protein, cholesterol, and albumin, were measured. The serum level of malondialdehyde, total antioxidant capacity, and hematological parameters were determined and compared among groups. Additionally, histopathological changes were investigated using light microscopy. Biochemical analysis showed significant improvement in bilirubin levels, total protein, cholesterol, and albumin in sheep treated with silymarin and clorsulon (p<0.05). Total antioxidant capacity increased in group treated with silymarin (p<0.05) compared to group 2, and the amount of oxidative stress decreased (p<0.01). Silymarin also improved hematologic factors and prevented a decrease in red blood cells (p<0.05). Liver inflammation, fibrosis, necrosis, and hyperplasia of the bile duct decreased significantly with the silymarin and clorsulon group compared to the other groups (p<0.0001). These findings showed that using silymarin in combination with clorsulon improved their therapeutic effects in treatment of ovine fasciolosis through enhancement of pharmacokinetic and pharmacodynamic relationship. |
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