Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon

Fasciolosis is a parasitic disease that causes economic losses. ‎In the present study, the protective effects of silymarin alone and in ‎combination with clorsulon were investigated in sheep naturally infected with ‎Fasciola hepatica. For this purpose, 40 Sangsari breed sheep ‎were used, which were...

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Autores principales:	Mehrzad Aflatooni, negar panahi, Pejman Mortazavi, Bahar Shemshadi, Shapoor Kakoolaki
Formato:	article
Lenguaje:	FA
Publicado:	Islamic Azad University, Tabriz Branch 2021
Materias:	malondialdehyde ovine fasciolosis pharmacokinetic total antioxidant capacity Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b2af70f801dd4196bff7cfc61fdae874
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spelling	oai:doaj.org-article:b2af70f801dd4196bff7cfc61fdae8742021-11-09T05:50:21ZProtective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon2322-47462476-698410.30495/jvcp.2021.1918402.1288https://doaj.org/article/b2af70f801dd4196bff7cfc61fdae8742021-07-01T00:00:00Zhttp://jvcp.iaut.ac.ir/article_684256_bb055578964d50dd2e7bcd4f15c6a8f1.pdfhttps://doaj.org/toc/2322-4746https://doaj.org/toc/2476-6984Fasciolosis is a parasitic disease that causes economic losses. ‎In the present study, the protective effects of silymarin alone and in ‎combination with clorsulon were investigated in sheep naturally infected with ‎Fasciola hepatica. For this purpose, 40 Sangsari breed sheep ‎were used, which were divided into five groups, including 1- healthy sheep without treatment 2- ‎fasciolosis affected sheep without treatment 3- fasciolosis affected sheep treated with silymarin 4- fasciolosis affected sheep treated with ‎Clorsulon, and 5- fasciolosis affected sheep treated with silymarin ‎and clorsulon. Biochemical parameters including triglyceride, total bilirubin, total protein, cholesterol, and albumin, were ‎measured. The serum level of malondialdehyde, total antioxidant capacity, and ‎hematological parameters were determined and compared among groups. Additionally, histopathological changes ‎were ‎‎‎investigated using light microscopy. Biochemical analysis showed significant ‎improvement in bilirubin levels, total protein, cholesterol, and albumin in sheep treated with silymarin ‎and clorsulon (p<0.05). Total antioxidant capacity increased in group treated with silymarin (p<0.05) compared to group 2, and the amount of oxidative stress decreased (p<0.01). Silymarin also improved hematologic factors and prevented a decrease in red blood cells (p<0.05).‎ Liver inflammation, ‎fibrosis, necrosis, and hyperplasia of the ‎bile ‎duct decreased significantly with the silymarin and ‎clorsulon group compared to the other groups ‎‎(p<0.0001). These findings ‎showed that using ‎silymarin in combination with clorsulon ‎improved their ‎therapeutic effects in treatment of ovine fasciolosis through enhancement of pharmacokinetic and pharmacodynamic relationship.Mehrzad Aflatooninegar panahiPejman MortazaviBahar ShemshadiShapoor KakoolakiIslamic Azad University, Tabriz Brancharticlemalondialdehydeovine fasciolosispharmacokinetictotal antioxidant capacityVeterinary medicineSF600-1100FAĀsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, Vol 15, Iss 2 (58) تابستان, Pp 169-186 (2021)
institution	DOAJ
collection	DOAJ
language	FA
topic	malondialdehyde ovine fasciolosis pharmacokinetic total antioxidant capacity Veterinary medicine SF600-1100
spellingShingle	malondialdehyde ovine fasciolosis pharmacokinetic total antioxidant capacity Veterinary medicine SF600-1100 Mehrzad Aflatooni negar panahi Pejman Mortazavi Bahar Shemshadi Shapoor Kakoolaki Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
description	Fasciolosis is a parasitic disease that causes economic losses. ‎In the present study, the protective effects of silymarin alone and in ‎combination with clorsulon were investigated in sheep naturally infected with ‎Fasciola hepatica. For this purpose, 40 Sangsari breed sheep ‎were used, which were divided into five groups, including 1- healthy sheep without treatment 2- ‎fasciolosis affected sheep without treatment 3- fasciolosis affected sheep treated with silymarin 4- fasciolosis affected sheep treated with ‎Clorsulon, and 5- fasciolosis affected sheep treated with silymarin ‎and clorsulon. Biochemical parameters including triglyceride, total bilirubin, total protein, cholesterol, and albumin, were ‎measured. The serum level of malondialdehyde, total antioxidant capacity, and ‎hematological parameters were determined and compared among groups. Additionally, histopathological changes ‎were ‎‎‎investigated using light microscopy. Biochemical analysis showed significant ‎improvement in bilirubin levels, total protein, cholesterol, and albumin in sheep treated with silymarin ‎and clorsulon (p<0.05). Total antioxidant capacity increased in group treated with silymarin (p<0.05) compared to group 2, and the amount of oxidative stress decreased (p<0.01). Silymarin also improved hematologic factors and prevented a decrease in red blood cells (p<0.05).‎ Liver inflammation, ‎fibrosis, necrosis, and hyperplasia of the ‎bile ‎duct decreased significantly with the silymarin and ‎clorsulon group compared to the other groups ‎‎(p<0.0001). These findings ‎showed that using ‎silymarin in combination with clorsulon ‎improved their ‎therapeutic effects in treatment of ovine fasciolosis through enhancement of pharmacokinetic and pharmacodynamic relationship.
format	article
author	Mehrzad Aflatooni negar panahi Pejman Mortazavi Bahar Shemshadi Shapoor Kakoolaki
author_facet	Mehrzad Aflatooni negar panahi Pejman Mortazavi Bahar Shemshadi Shapoor Kakoolaki
author_sort	Mehrzad Aflatooni
title	Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
title_short	Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
title_full	Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
title_fullStr	Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
title_full_unstemmed	Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
title_sort	protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
publisher	Islamic Azad University, Tabriz Branch
publishDate	2021
url	https://doaj.org/article/b2af70f801dd4196bff7cfc61fdae874
work_keys_str_mv	AT mehrzadaflatooni protectiveandantioxidanteffectsofsilymarininsheepwithfasciolosistreatedbyclorsulon AT negarpanahi protectiveandantioxidanteffectsofsilymarininsheepwithfasciolosistreatedbyclorsulon AT pejmanmortazavi protectiveandantioxidanteffectsofsilymarininsheepwithfasciolosistreatedbyclorsulon AT baharshemshadi protectiveandantioxidanteffectsofsilymarininsheepwithfasciolosistreatedbyclorsulon AT shapoorkakoolaki protectiveandantioxidanteffectsofsilymarininsheepwithfasciolosistreatedbyclorsulon
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Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon

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