Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

Genome-wide libraries for CRISPR knockout, interference, and activation have allowed the systemic interrogation of gene function. Here, the authors evaluate the Brunello CRISPRko library and introduce Dolcetto and Calabrese for CRISPRi and CRISPRa, respectively.

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Detalles Bibliográficos
Autores principales: Kendall R. Sanson, Ruth E. Hanna, Mudra Hegde, Katherine F. Donovan, Christine Strand, Meagan E. Sullender, Emma W. Vaimberg, Amy Goodale, David E. Root, Federica Piccioni, John G. Doench
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/b2b3b6edfdcb4b859c371ceb1069d5c6
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https://doaj.org/article/b2b3b6edfdcb4b859c371ceb1069d5c6

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