Restoration of energy homeostasis by SIRT6 extends healthy lifespan
Aging is associated with increased frailty and disrupted energy homeostasis. Here, the authors show that SIRT6 overexpression extends the lifespan of male and female mice and demonstrate that SIRT6 optimizes energy homeostasis in old age, which delays frailty and preserves healthy aging.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b2bf589793d04d27ae041eead4489a7f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b2bf589793d04d27ae041eead4489a7f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b2bf589793d04d27ae041eead4489a7f2021-12-02T14:49:22ZRestoration of energy homeostasis by SIRT6 extends healthy lifespan10.1038/s41467-021-23545-72041-1723https://doaj.org/article/b2bf589793d04d27ae041eead4489a7f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23545-7https://doaj.org/toc/2041-1723Aging is associated with increased frailty and disrupted energy homeostasis. Here, the authors show that SIRT6 overexpression extends the lifespan of male and female mice and demonstrate that SIRT6 optimizes energy homeostasis in old age, which delays frailty and preserves healthy aging.A. RoichmanS. ElhanatiM. A. AonI. AbramovichA. Di FrancescoY. ShaharM. Y. AviviM. ShurgiA. RubinsteinY. WiesnerA. ShuchamiZ. PetroverI. Lebenthal-LoingerO. YaronA. LyashkovC. Ubaida-MohienY. KanfiB. LerrerP. J. Fernández-MarcosM. SerranoE. GottliebR. de CaboH. Y. CohenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q A. Roichman S. Elhanati M. A. Aon I. Abramovich A. Di Francesco Y. Shahar M. Y. Avivi M. Shurgi A. Rubinstein Y. Wiesner A. Shuchami Z. Petrover I. Lebenthal-Loinger O. Yaron A. Lyashkov C. Ubaida-Mohien Y. Kanfi B. Lerrer P. J. Fernández-Marcos M. Serrano E. Gottlieb R. de Cabo H. Y. Cohen Restoration of energy homeostasis by SIRT6 extends healthy lifespan |
| description |
Aging is associated with increased frailty and disrupted energy homeostasis. Here, the authors show that SIRT6 overexpression extends the lifespan of male and female mice and demonstrate that SIRT6 optimizes energy homeostasis in old age, which delays frailty and preserves healthy aging. |
| format |
article |
| author |
A. Roichman S. Elhanati M. A. Aon I. Abramovich A. Di Francesco Y. Shahar M. Y. Avivi M. Shurgi A. Rubinstein Y. Wiesner A. Shuchami Z. Petrover I. Lebenthal-Loinger O. Yaron A. Lyashkov C. Ubaida-Mohien Y. Kanfi B. Lerrer P. J. Fernández-Marcos M. Serrano E. Gottlieb R. de Cabo H. Y. Cohen |
| author_facet |
A. Roichman S. Elhanati M. A. Aon I. Abramovich A. Di Francesco Y. Shahar M. Y. Avivi M. Shurgi A. Rubinstein Y. Wiesner A. Shuchami Z. Petrover I. Lebenthal-Loinger O. Yaron A. Lyashkov C. Ubaida-Mohien Y. Kanfi B. Lerrer P. J. Fernández-Marcos M. Serrano E. Gottlieb R. de Cabo H. Y. Cohen |
| author_sort |
A. Roichman |
| title |
Restoration of energy homeostasis by SIRT6 extends healthy lifespan |
| title_short |
Restoration of energy homeostasis by SIRT6 extends healthy lifespan |
| title_full |
Restoration of energy homeostasis by SIRT6 extends healthy lifespan |
| title_fullStr |
Restoration of energy homeostasis by SIRT6 extends healthy lifespan |
| title_full_unstemmed |
Restoration of energy homeostasis by SIRT6 extends healthy lifespan |
| title_sort |
restoration of energy homeostasis by sirt6 extends healthy lifespan |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b2bf589793d04d27ae041eead4489a7f |
| work_keys_str_mv |
AT aroichman restorationofenergyhomeostasisbysirt6extendshealthylifespan AT selhanati restorationofenergyhomeostasisbysirt6extendshealthylifespan AT maaon restorationofenergyhomeostasisbysirt6extendshealthylifespan AT iabramovich restorationofenergyhomeostasisbysirt6extendshealthylifespan AT adifrancesco restorationofenergyhomeostasisbysirt6extendshealthylifespan AT yshahar restorationofenergyhomeostasisbysirt6extendshealthylifespan AT myavivi restorationofenergyhomeostasisbysirt6extendshealthylifespan AT mshurgi restorationofenergyhomeostasisbysirt6extendshealthylifespan AT arubinstein restorationofenergyhomeostasisbysirt6extendshealthylifespan AT ywiesner restorationofenergyhomeostasisbysirt6extendshealthylifespan AT ashuchami restorationofenergyhomeostasisbysirt6extendshealthylifespan AT zpetrover restorationofenergyhomeostasisbysirt6extendshealthylifespan AT ilebenthalloinger restorationofenergyhomeostasisbysirt6extendshealthylifespan AT oyaron restorationofenergyhomeostasisbysirt6extendshealthylifespan AT alyashkov restorationofenergyhomeostasisbysirt6extendshealthylifespan AT cubaidamohien restorationofenergyhomeostasisbysirt6extendshealthylifespan AT ykanfi restorationofenergyhomeostasisbysirt6extendshealthylifespan AT blerrer restorationofenergyhomeostasisbysirt6extendshealthylifespan AT pjfernandezmarcos restorationofenergyhomeostasisbysirt6extendshealthylifespan AT mserrano restorationofenergyhomeostasisbysirt6extendshealthylifespan AT egottlieb restorationofenergyhomeostasisbysirt6extendshealthylifespan AT rdecabo restorationofenergyhomeostasisbysirt6extendshealthylifespan AT hycohen restorationofenergyhomeostasisbysirt6extendshealthylifespan |
| _version_ |
1718389530283737088 |