Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats

To evaluate the efficiency of the probiotic strain Lactobacillus plantarum LS/07 in dextran sulphate sodium (DSS) induced acute colitis selected biochemical (activity of β-glucuronidase), microbiological (counts of lactobacilli and coliforms), and immunological (IL-6, IL-8, IL-13, NF-κB, MPO) parame...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emília Hijová, Izabela Bertková, Jana Štofilová, Ladislav Strojný, Anna Chmelárová, Alojz Bomba
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	sprague-dawley rats colitis inflammation lactobacillus plantarum ls/07 Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b2c0d26c30054796ab45dbf9565116cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b2c0d26c30054796ab45dbf9565116cd
record_format	dspace
spelling	oai:doaj.org-article:b2c0d26c30054796ab45dbf9565116cd2021-11-17T21:27:52ZAnti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats1820-744810.2478/acve-2018-0005https://doaj.org/article/b2c0d26c30054796ab45dbf9565116cd2018-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2018-0005https://doaj.org/toc/1820-7448To evaluate the efficiency of the probiotic strain Lactobacillus plantarum LS/07 in dextran sulphate sodium (DSS) induced acute colitis selected biochemical (activity of β-glucuronidase), microbiological (counts of lactobacilli and coliforms), and immunological (IL-6, IL-8, IL-13, NF-κB, MPO) parameters were assessed. Sprague-Dawley rats were divided into groups: Control, Acute colitis, and Probiotic. Acute colitis was induced using 5% DSS in drinking water for 7d. DSS induced an inflammatory process in the colonic tissue, increased the activity of β-glucuronidase (p<0.001), increased the counts of coliform bacteria and decreased lactobacilli counts (p<0.05), and activated the production of the measured parameters (NF-κB, MPO, IL-6, IL-8) except of IL-13. Lactobacillus plantarum LS/07 in the diet alleviated the DSS induced inflammatory process by inhibiting the production of IL-6, IL-8, the activities of NF-κB and MPO, and stimulated the production of IL-13. The probiotic reduced the activity of β-glucuronidase (p<0.05), increased lactobacilli counts and decreased coliform bacteria. These results indicate that dietary intake of Lactobacillus plantarum LS/07 suppressed the expression of markers playing an important role in the inflammatory process. We conclude that the anti-inflammatory properties of Lactobacillus plantarum LS/07 makes its suitable for the prevention or treatment of colitis.Emília HijováIzabela BertkováJana ŠtofilováLadislav StrojnýAnna ChmelárováAlojz BombaSciendoarticlesprague-dawley ratscolitisinflammationlactobacillus plantarum ls/07Veterinary medicineSF600-1100ENActa Veterinaria, Vol 68, Iss 1, Pp 55-64 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	sprague-dawley rats colitis inflammation lactobacillus plantarum ls/07 Veterinary medicine SF600-1100
spellingShingle	sprague-dawley rats colitis inflammation lactobacillus plantarum ls/07 Veterinary medicine SF600-1100 Emília Hijová Izabela Bertková Jana Štofilová Ladislav Strojný Anna Chmelárová Alojz Bomba Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats
description	To evaluate the efficiency of the probiotic strain Lactobacillus plantarum LS/07 in dextran sulphate sodium (DSS) induced acute colitis selected biochemical (activity of β-glucuronidase), microbiological (counts of lactobacilli and coliforms), and immunological (IL-6, IL-8, IL-13, NF-κB, MPO) parameters were assessed. Sprague-Dawley rats were divided into groups: Control, Acute colitis, and Probiotic. Acute colitis was induced using 5% DSS in drinking water for 7d. DSS induced an inflammatory process in the colonic tissue, increased the activity of β-glucuronidase (p<0.001), increased the counts of coliform bacteria and decreased lactobacilli counts (p<0.05), and activated the production of the measured parameters (NF-κB, MPO, IL-6, IL-8) except of IL-13. Lactobacillus plantarum LS/07 in the diet alleviated the DSS induced inflammatory process by inhibiting the production of IL-6, IL-8, the activities of NF-κB and MPO, and stimulated the production of IL-13. The probiotic reduced the activity of β-glucuronidase (p<0.05), increased lactobacilli counts and decreased coliform bacteria. These results indicate that dietary intake of Lactobacillus plantarum LS/07 suppressed the expression of markers playing an important role in the inflammatory process. We conclude that the anti-inflammatory properties of Lactobacillus plantarum LS/07 makes its suitable for the prevention or treatment of colitis.
format	article
author	Emília Hijová Izabela Bertková Jana Štofilová Ladislav Strojný Anna Chmelárová Alojz Bomba
author_facet	Emília Hijová Izabela Bertková Jana Štofilová Ladislav Strojný Anna Chmelárová Alojz Bomba
author_sort	Emília Hijová
title	Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats
title_short	Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats
title_full	Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats
title_fullStr	Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats
title_full_unstemmed	Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats
title_sort	anti-inflammatory potential of lactobacillus plantarum ls/07 in acute colitis in rats
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/b2c0d26c30054796ab45dbf9565116cd
work_keys_str_mv	AT emiliahijova antiinflammatorypotentialoflactobacillusplantarumls07inacutecolitisinrats AT izabelabertkova antiinflammatorypotentialoflactobacillusplantarumls07inacutecolitisinrats AT janastofilova antiinflammatorypotentialoflactobacillusplantarumls07inacutecolitisinrats AT ladislavstrojny antiinflammatorypotentialoflactobacillusplantarumls07inacutecolitisinrats AT annachmelarova antiinflammatorypotentialoflactobacillusplantarumls07inacutecolitisinrats AT alojzbomba antiinflammatorypotentialoflactobacillusplantarumls07inacutecolitisinrats
_version_	1718425308698247168

Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats

Ejemplares similares