Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

TDP-43 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTD-TDP). Here, the authors identify the transcriptional elongation factor Ell as a strong modifier of TDP-43-mediated neurodegeneration through the Ell transcriptional...

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Autores principales:	Chia-Yu Chung, Amit Berson, Jason R. Kennerdell, Ashley Sartoris, Travis Unger, Sílvia Porta, Hyung-Jun Kim, Edwin R. Smith, Ali Shilatifard, Vivianna Van Deerlin, Virginia M.-Y. Lee, Alice Chen-Plotkin, Nancy M. Bonini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b2c2979de7ba485791653b7eba03aec1
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spelling	oai:doaj.org-article:b2c2979de7ba485791653b7eba03aec12021-12-02T16:50:12ZAberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity10.1038/s41467-018-06543-02041-1723https://doaj.org/article/b2c2979de7ba485791653b7eba03aec12018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06543-0https://doaj.org/toc/2041-1723TDP-43 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTD-TDP). Here, the authors identify the transcriptional elongation factor Ell as a strong modifier of TDP-43-mediated neurodegeneration through the Ell transcriptional elongation complexes LEC and SEC.Chia-Yu ChungAmit BersonJason R. KennerdellAshley SartorisTravis UngerSílvia PortaHyung-Jun KimEdwin R. SmithAli ShilatifardVivianna Van DeerlinVirginia M.-Y. LeeAlice Chen-PlotkinNancy M. BoniniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chia-Yu Chung Amit Berson Jason R. Kennerdell Ashley Sartoris Travis Unger Sílvia Porta Hyung-Jun Kim Edwin R. Smith Ali Shilatifard Vivianna Van Deerlin Virginia M.-Y. Lee Alice Chen-Plotkin Nancy M. Bonini Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
description	TDP-43 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTD-TDP). Here, the authors identify the transcriptional elongation factor Ell as a strong modifier of TDP-43-mediated neurodegeneration through the Ell transcriptional elongation complexes LEC and SEC.
format	article
author	Chia-Yu Chung Amit Berson Jason R. Kennerdell Ashley Sartoris Travis Unger Sílvia Porta Hyung-Jun Kim Edwin R. Smith Ali Shilatifard Vivianna Van Deerlin Virginia M.-Y. Lee Alice Chen-Plotkin Nancy M. Bonini
author_facet	Chia-Yu Chung Amit Berson Jason R. Kennerdell Ashley Sartoris Travis Unger Sílvia Porta Hyung-Jun Kim Edwin R. Smith Ali Shilatifard Vivianna Van Deerlin Virginia M.-Y. Lee Alice Chen-Plotkin Nancy M. Bonini
author_sort	Chia-Yu Chung
title	Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
title_short	Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
title_full	Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
title_fullStr	Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
title_full_unstemmed	Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
title_sort	aberrant activation of non-coding rna targets of transcriptional elongation complexes contributes to tdp-43 toxicity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b2c2979de7ba485791653b7eba03aec1
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Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

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