Comparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma

Background: This study aimed to compare the controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and geriatric nutritional risk index (GNRI) for predicting postoperative outcomes in patients with esophageal squamous cell carcinoma undergoing esophagectomy. Methods: We re...

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Autores principales:	Jung-Pil Yoon, Jae-Sik Nam, Mohd Fitry Bin Zainal Abidin, Seon-Ok Kim, Eun-Ho Lee, In-Cheol Choi, Ji-Hyun Chin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	esophageal cancer controlling nutritional status score prognostic nutritional index geriatric nutritional risk index survival Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b2c61eb972374cc2baf5ca751e4d718f
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spelling	oai:doaj.org-article:b2c61eb972374cc2baf5ca751e4d718f2021-11-25T18:36:38ZComparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma10.3390/nu131140862072-6643https://doaj.org/article/b2c61eb972374cc2baf5ca751e4d718f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4086https://doaj.org/toc/2072-6643Background: This study aimed to compare the controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and geriatric nutritional risk index (GNRI) for predicting postoperative outcomes in patients with esophageal squamous cell carcinoma undergoing esophagectomy. Methods: We retrospectively reviewed the data of 1265 consecutive patients who underwent elective esophageal surgery. The patients were classified into no risk, low-risk, moderate-risk, and high-risk groups based on nutritional scores. Results: The moderate-risk (hazard ratio [HR]: 1.55, 95% confidence interval [CI]: 1.24–1.92, <i>p</i> < 0.001 in CONUT; HR: 1.61, 95% CI: 1.22–2.12, <i>p</i> = 0.001 in GNRI; HR: 1.65, 95% CI: 1.20–2.26, <i>p</i> = 0.002 in PNI) and high-risk groups (HR: 1.91, 95% CI: 1.47–2.48, <i>p</i> < 0.001 in CONUT; HR: 2.54, 95% CI: 1.64–3.93, <i>p</i> < 0.001 in GNRI; HR: 2.32, 95% CI: 1.77–3.06, <i>p</i> < 0.001 in PNI) exhibited significantly worse 5-year overall survival (OS) compared with the no-risk group. As the nutritional status worsened, the trend in the OS rates decreased (<i>p</i> for trend in all indexes < 0.05). Conclusions: Malnutrition, evaluated by any of three nutritional indexes, was an independent prognostic factor for postoperative survival.Jung-Pil YoonJae-Sik NamMohd Fitry Bin Zainal AbidinSeon-Ok KimEun-Ho LeeIn-Cheol ChoiJi-Hyun ChinMDPI AGarticleesophageal cancercontrolling nutritional status scoreprognostic nutritional indexgeriatric nutritional risk indexsurvivalNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4086, p 4086 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophageal cancer controlling nutritional status score prognostic nutritional index geriatric nutritional risk index survival Nutrition. Foods and food supply TX341-641
spellingShingle	esophageal cancer controlling nutritional status score prognostic nutritional index geriatric nutritional risk index survival Nutrition. Foods and food supply TX341-641 Jung-Pil Yoon Jae-Sik Nam Mohd Fitry Bin Zainal Abidin Seon-Ok Kim Eun-Ho Lee In-Cheol Choi Ji-Hyun Chin Comparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma
description	Background: This study aimed to compare the controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and geriatric nutritional risk index (GNRI) for predicting postoperative outcomes in patients with esophageal squamous cell carcinoma undergoing esophagectomy. Methods: We retrospectively reviewed the data of 1265 consecutive patients who underwent elective esophageal surgery. The patients were classified into no risk, low-risk, moderate-risk, and high-risk groups based on nutritional scores. Results: The moderate-risk (hazard ratio [HR]: 1.55, 95% confidence interval [CI]: 1.24–1.92, <i>p</i> < 0.001 in CONUT; HR: 1.61, 95% CI: 1.22–2.12, <i>p</i> = 0.001 in GNRI; HR: 1.65, 95% CI: 1.20–2.26, <i>p</i> = 0.002 in PNI) and high-risk groups (HR: 1.91, 95% CI: 1.47–2.48, <i>p</i> < 0.001 in CONUT; HR: 2.54, 95% CI: 1.64–3.93, <i>p</i> < 0.001 in GNRI; HR: 2.32, 95% CI: 1.77–3.06, <i>p</i> < 0.001 in PNI) exhibited significantly worse 5-year overall survival (OS) compared with the no-risk group. As the nutritional status worsened, the trend in the OS rates decreased (<i>p</i> for trend in all indexes < 0.05). Conclusions: Malnutrition, evaluated by any of three nutritional indexes, was an independent prognostic factor for postoperative survival.
format	article
author	Jung-Pil Yoon Jae-Sik Nam Mohd Fitry Bin Zainal Abidin Seon-Ok Kim Eun-Ho Lee In-Cheol Choi Ji-Hyun Chin
author_facet	Jung-Pil Yoon Jae-Sik Nam Mohd Fitry Bin Zainal Abidin Seon-Ok Kim Eun-Ho Lee In-Cheol Choi Ji-Hyun Chin
author_sort	Jung-Pil Yoon
title	Comparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma
title_short	Comparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma
title_full	Comparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma
title_fullStr	Comparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma
title_full_unstemmed	Comparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma
title_sort	comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b2c61eb972374cc2baf5ca751e4d718f
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Comparison of Preoperative Nutritional Indexes for Outcomes after Primary Esophageal Surgery for Esophageal Squamous Cell Carcinoma

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