Prostate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?

ObjectivesTo investigate the impact of ultrasound shear wave elastography (USWE) and multiparametric magnetic resonance imaging (mpMRI) in predicting a change in biopsy-assigned Gleason Score (GS) after radical surgery for localised prostate cancer (PCa).MethodA total of 212 men opting for laparosco...

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Autores principales:	Cheng Wei, Yilong Zhang, Xinyu Zhang, Wael Ageeli, Magdalena Szewczyk-Bieda, Jonathan Serhan, Jennifer Wilson, Chunhui Li, Ghulam Nabi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	prostate cancer ultrasound shear wave elastography multiparametric MRI PIRADS radical prostatectomy prostate biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b2c863a4908947c493d6ae23996e581c
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spelling	oai:doaj.org-article:b2c863a4908947c493d6ae23996e581c2021-11-30T11:53:22ZProstate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?2234-943X10.3389/fonc.2021.740724https://doaj.org/article/b2c863a4908947c493d6ae23996e581c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.740724/fullhttps://doaj.org/toc/2234-943XObjectivesTo investigate the impact of ultrasound shear wave elastography (USWE) and multiparametric magnetic resonance imaging (mpMRI) in predicting a change in biopsy-assigned Gleason Score (GS) after radical surgery for localised prostate cancer (PCa).MethodA total of 212 men opting for laparoscopic radical prostatectomy (LRP) between September 2013 and June 2017 were recruited into this study. All the participants had 12-core transrectal ultrasound (TRUS) biopsies and imaging using USWE and mpMRI before radical surgery. The predictive accuracy for imaging modalities was assessed in relation to upgrading and downgrading of PCa GS between the biopsies and radical prostatectomy using Student’s t-test and multivariable logistic regression analyses. A decision analysis curve was constructed assessing the impact of nomogram on clinical situations using different thresholds of upgrading probabilities.ResultsMost GS 6 diseases on biopsies were upgraded on radical surgery (37/42, 88.1%). Major downgrading was seen in GS 8 category of disease (14/35; 37.1%), whereas no alteration was observed in GS 7 on biopsies in most men (55/75; 73.3%). In univariate analysis, higher preoperative prostate-specific antigen (PSA) (p = 0.001), higher prostate-specific antigen density (PSAD) (p = 0.002), stiffer USWE lesions (p = 0.009), and higher prostate imaging–reporting and data system (PIRADS) (p = 0.002) on mpMRI were significant predictors of upgrading. In multivariate logistic regression analyses, only PSA (p = 0.016) and USWE-measured tissue stiffness (p = 0.029) showed statistical significance in predicting upgrading.ConclusionsMeasurement of tissue stiffness using USWE in clinically localised PCa can predict upgrading of GS and has the potential to improve patient management options.Cheng WeiYilong ZhangXinyu ZhangWael AgeeliWael AgeeliMagdalena Szewczyk-BiedaJonathan SerhanJennifer WilsonChunhui LiGhulam NabiFrontiers Media S.A.articleprostate cancerultrasound shear wave elastographymultiparametric MRIPIRADSradical prostatectomyprostate biopsyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer ultrasound shear wave elastography multiparametric MRI PIRADS radical prostatectomy prostate biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	prostate cancer ultrasound shear wave elastography multiparametric MRI PIRADS radical prostatectomy prostate biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cheng Wei Yilong Zhang Xinyu Zhang Wael Ageeli Wael Ageeli Magdalena Szewczyk-Bieda Jonathan Serhan Jennifer Wilson Chunhui Li Ghulam Nabi Prostate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?
description	ObjectivesTo investigate the impact of ultrasound shear wave elastography (USWE) and multiparametric magnetic resonance imaging (mpMRI) in predicting a change in biopsy-assigned Gleason Score (GS) after radical surgery for localised prostate cancer (PCa).MethodA total of 212 men opting for laparoscopic radical prostatectomy (LRP) between September 2013 and June 2017 were recruited into this study. All the participants had 12-core transrectal ultrasound (TRUS) biopsies and imaging using USWE and mpMRI before radical surgery. The predictive accuracy for imaging modalities was assessed in relation to upgrading and downgrading of PCa GS between the biopsies and radical prostatectomy using Student’s t-test and multivariable logistic regression analyses. A decision analysis curve was constructed assessing the impact of nomogram on clinical situations using different thresholds of upgrading probabilities.ResultsMost GS 6 diseases on biopsies were upgraded on radical surgery (37/42, 88.1%). Major downgrading was seen in GS 8 category of disease (14/35; 37.1%), whereas no alteration was observed in GS 7 on biopsies in most men (55/75; 73.3%). In univariate analysis, higher preoperative prostate-specific antigen (PSA) (p = 0.001), higher prostate-specific antigen density (PSAD) (p = 0.002), stiffer USWE lesions (p = 0.009), and higher prostate imaging–reporting and data system (PIRADS) (p = 0.002) on mpMRI were significant predictors of upgrading. In multivariate logistic regression analyses, only PSA (p = 0.016) and USWE-measured tissue stiffness (p = 0.029) showed statistical significance in predicting upgrading.ConclusionsMeasurement of tissue stiffness using USWE in clinically localised PCa can predict upgrading of GS and has the potential to improve patient management options.
format	article
author	Cheng Wei Yilong Zhang Xinyu Zhang Wael Ageeli Wael Ageeli Magdalena Szewczyk-Bieda Jonathan Serhan Jennifer Wilson Chunhui Li Ghulam Nabi
author_facet	Cheng Wei Yilong Zhang Xinyu Zhang Wael Ageeli Wael Ageeli Magdalena Szewczyk-Bieda Jonathan Serhan Jennifer Wilson Chunhui Li Ghulam Nabi
author_sort	Cheng Wei
title	Prostate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?
title_short	Prostate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?
title_full	Prostate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?
title_fullStr	Prostate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?
title_full_unstemmed	Prostate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?
title_sort	prostate cancer gleason score from biopsy to radical surgery: can ultrasound shear wave elastography and multiparametric magnetic resonance imaging narrow the gap?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b2c863a4908947c493d6ae23996e581c
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Prostate Cancer Gleason Score From Biopsy to Radical Surgery: Can Ultrasound Shear Wave Elastography and Multiparametric Magnetic Resonance Imaging Narrow the Gap?

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