Prognostic significance of tumor laterality in advanced ovarian cancer

Objective This study aimed to investigate the effect of incorporating tumor laterality into the International Federation of Gynecology and Obstetrics (FIGO) staging system for advanced ovarian cancer. Methods The clinical data of 131 patients with advanced ovarian cancer treated between 2008 and 201...

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Autores principales:	Yuki Yamada, Seiji Mabuchi, Naoki Kawahara, Ryuji Kawaguchi
Formato:	article
Lenguaje:	EN KO
Publicado:	Korean Society of Obstetrics and Gynecology 2021
Materias:	figo staging system ovarian cancer prognosis risk factors tumor laterality Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/b2cabcd0baf548c687ea5cfb1381694c
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spelling	oai:doaj.org-article:b2cabcd0baf548c687ea5cfb1381694c2021-11-15T00:50:16ZPrognostic significance of tumor laterality in advanced ovarian cancer2287-85722287-858010.5468/ogs.21176https://doaj.org/article/b2cabcd0baf548c687ea5cfb1381694c2021-11-01T00:00:00Zhttp://www.ogscience.org/upload/pdf/ogs-21176.pdfhttps://doaj.org/toc/2287-8572https://doaj.org/toc/2287-8580Objective This study aimed to investigate the effect of incorporating tumor laterality into the International Federation of Gynecology and Obstetrics (FIGO) staging system for advanced ovarian cancer. Methods The clinical data of 131 patients with advanced ovarian cancer treated between 2008 and 2018 were retrospectively reviewed. To investigate the prognostic significance of tumor laterality, we divided the patients into unilateral and bilateral groups. The prognostic significance of tumor laterality (bilateral vs. unilateral) was evaluated using univariate and multivariate analyses. The effect of incorporating tumor laterality into the FIGO staging system to predict survival outcomes was evaluated using the Kaplan-Meier method. Results Both overall survival (OS) and progression-free survival (PFS) were longer in the unilateral group than in the bilateral group. Multivariate analysis demonstrated that tumor laterality was an independent predictor of OS (hazard ratio, 1.75; confidence interval, 1.05-2.92; P=0.032). In patients with stage III disease, the bilateral group had a shorter OS than the unilateral group, but it was comparable to the OS in stage IV patients (P=0.354). The incorporation of tumor laterality into the FIGO staging system improved the stratification of survival probabilities. Conclusion Tumor laterality can be an independent prognostic factor in patients with advanced ovarian cancer. The incorporation of tumor laterality may improve the predictive performance of the FIGO staging system in patients with advanced ovarian cancer.Yuki YamadaSeiji MabuchiNaoki KawaharaRyuji KawaguchiKorean Society of Obstetrics and Gynecologyarticlefigo staging systemovarian cancerprognosisrisk factorstumor lateralityGynecology and obstetricsRG1-991ENKOObstetrics & Gynecology Science, Vol 64, Iss 6, Pp 524-531 (2021)
institution	DOAJ
collection	DOAJ
language	EN KO
topic	figo staging system ovarian cancer prognosis risk factors tumor laterality Gynecology and obstetrics RG1-991
spellingShingle	figo staging system ovarian cancer prognosis risk factors tumor laterality Gynecology and obstetrics RG1-991 Yuki Yamada Seiji Mabuchi Naoki Kawahara Ryuji Kawaguchi Prognostic significance of tumor laterality in advanced ovarian cancer
description	Objective This study aimed to investigate the effect of incorporating tumor laterality into the International Federation of Gynecology and Obstetrics (FIGO) staging system for advanced ovarian cancer. Methods The clinical data of 131 patients with advanced ovarian cancer treated between 2008 and 2018 were retrospectively reviewed. To investigate the prognostic significance of tumor laterality, we divided the patients into unilateral and bilateral groups. The prognostic significance of tumor laterality (bilateral vs. unilateral) was evaluated using univariate and multivariate analyses. The effect of incorporating tumor laterality into the FIGO staging system to predict survival outcomes was evaluated using the Kaplan-Meier method. Results Both overall survival (OS) and progression-free survival (PFS) were longer in the unilateral group than in the bilateral group. Multivariate analysis demonstrated that tumor laterality was an independent predictor of OS (hazard ratio, 1.75; confidence interval, 1.05-2.92; P=0.032). In patients with stage III disease, the bilateral group had a shorter OS than the unilateral group, but it was comparable to the OS in stage IV patients (P=0.354). The incorporation of tumor laterality into the FIGO staging system improved the stratification of survival probabilities. Conclusion Tumor laterality can be an independent prognostic factor in patients with advanced ovarian cancer. The incorporation of tumor laterality may improve the predictive performance of the FIGO staging system in patients with advanced ovarian cancer.
format	article
author	Yuki Yamada Seiji Mabuchi Naoki Kawahara Ryuji Kawaguchi
author_facet	Yuki Yamada Seiji Mabuchi Naoki Kawahara Ryuji Kawaguchi
author_sort	Yuki Yamada
title	Prognostic significance of tumor laterality in advanced ovarian cancer
title_short	Prognostic significance of tumor laterality in advanced ovarian cancer
title_full	Prognostic significance of tumor laterality in advanced ovarian cancer
title_fullStr	Prognostic significance of tumor laterality in advanced ovarian cancer
title_full_unstemmed	Prognostic significance of tumor laterality in advanced ovarian cancer
title_sort	prognostic significance of tumor laterality in advanced ovarian cancer
publisher	Korean Society of Obstetrics and Gynecology
publishDate	2021
url	https://doaj.org/article/b2cabcd0baf548c687ea5cfb1381694c
work_keys_str_mv	AT yukiyamada prognosticsignificanceoftumorlateralityinadvancedovariancancer AT seijimabuchi prognosticsignificanceoftumorlateralityinadvancedovariancancer AT naokikawahara prognosticsignificanceoftumorlateralityinadvancedovariancancer AT ryujikawaguchi prognosticsignificanceoftumorlateralityinadvancedovariancancer
_version_	1718429004991561728

Prognostic significance of tumor laterality in advanced ovarian cancer

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