TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with color...

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Autores principales: Laura Garcia Perez, Jan Kempski, Heather M. McGee, Penelope Pelzcar, Theodora Agalioti, Anastasios Giannou, Leonie Konczalla, Leonie Brockmann, Ramez Wahib, Hao Xu, Maria Carolina Amezcua Vesely, Shiwa Soukou, Babett Steglich, Tanja Bedke, Carolin Manthey, Oliver Seiz, Björn-Philipp Diercks, Stylianos Gnafakis, Andreas H. Guse, Daniel Perez, Jakob R. Izbicki, Nicola Gagliani, Richard A. Flavell, Samuel Huber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b2cd0a9890934f83bc2a0f45b98be1cc
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spelling oai:doaj.org-article:b2cd0a9890934f83bc2a0f45b98be1cc2021-12-02T14:47:29ZTGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer10.1038/s41467-020-16363-w2041-1723https://doaj.org/article/b2cd0a9890934f83bc2a0f45b98be1cc2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16363-whttps://doaj.org/toc/2041-1723Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with colorectal cancer (CRC) and drive CRC progression in mice.Laura Garcia PerezJan KempskiHeather M. McGeePenelope PelzcarTheodora AgaliotiAnastasios GiannouLeonie KonczallaLeonie BrockmannRamez WahibHao XuMaria Carolina Amezcua VeselyShiwa SoukouBabett SteglichTanja BedkeCarolin MantheyOliver SeizBjörn-Philipp DiercksStylianos GnafakisAndreas H. GuseDaniel PerezJakob R. IzbickiNicola GaglianiRichard A. FlavellSamuel HuberNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Laura Garcia Perez
Jan Kempski
Heather M. McGee
Penelope Pelzcar
Theodora Agalioti
Anastasios Giannou
Leonie Konczalla
Leonie Brockmann
Ramez Wahib
Hao Xu
Maria Carolina Amezcua Vesely
Shiwa Soukou
Babett Steglich
Tanja Bedke
Carolin Manthey
Oliver Seiz
Björn-Philipp Diercks
Stylianos Gnafakis
Andreas H. Guse
Daniel Perez
Jakob R. Izbicki
Nicola Gagliani
Richard A. Flavell
Samuel Huber
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
description Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with colorectal cancer (CRC) and drive CRC progression in mice.
format article
author Laura Garcia Perez
Jan Kempski
Heather M. McGee
Penelope Pelzcar
Theodora Agalioti
Anastasios Giannou
Leonie Konczalla
Leonie Brockmann
Ramez Wahib
Hao Xu
Maria Carolina Amezcua Vesely
Shiwa Soukou
Babett Steglich
Tanja Bedke
Carolin Manthey
Oliver Seiz
Björn-Philipp Diercks
Stylianos Gnafakis
Andreas H. Guse
Daniel Perez
Jakob R. Izbicki
Nicola Gagliani
Richard A. Flavell
Samuel Huber
author_facet Laura Garcia Perez
Jan Kempski
Heather M. McGee
Penelope Pelzcar
Theodora Agalioti
Anastasios Giannou
Leonie Konczalla
Leonie Brockmann
Ramez Wahib
Hao Xu
Maria Carolina Amezcua Vesely
Shiwa Soukou
Babett Steglich
Tanja Bedke
Carolin Manthey
Oliver Seiz
Björn-Philipp Diercks
Stylianos Gnafakis
Andreas H. Guse
Daniel Perez
Jakob R. Izbicki
Nicola Gagliani
Richard A. Flavell
Samuel Huber
author_sort Laura Garcia Perez
title TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
title_short TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
title_full TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
title_fullStr TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
title_full_unstemmed TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
title_sort tgf-β signaling in th17 cells promotes il-22 production and colitis-associated colon cancer
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b2cd0a9890934f83bc2a0f45b98be1cc
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