Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

Fibrotic scar tissue limits central nervous system regeneration. Here, Dias et al. show that fibrotic scarring is common in mice and humans, following distinct lesions to the adult brain and spinal cord, and derives from a discrete population of GLAST-expressing perivascular cells.

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Autores principales:	David O. Dias, Jannis Kalkitsas, Yildiz Kelahmetoglu, Cynthia P. Estrada, Jemal Tatarishvili, Daniel Holl, Linda Jansson, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Aurélie Ernst, Hagen B. Huttner, Zaal Kokaia, Olle Lindvall, Lou Brundin, Jonas Frisén, Christian Göritz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b2cf5ecacb394539a29e9965db99ad35
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spelling	oai:doaj.org-article:b2cf5ecacb394539a29e9965db99ad352021-12-02T17:23:40ZPericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions10.1038/s41467-021-25585-52041-1723https://doaj.org/article/b2cf5ecacb394539a29e9965db99ad352021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25585-5https://doaj.org/toc/2041-1723Fibrotic scar tissue limits central nervous system regeneration. Here, Dias et al. show that fibrotic scarring is common in mice and humans, following distinct lesions to the adult brain and spinal cord, and derives from a discrete population of GLAST-expressing perivascular cells.David O. DiasJannis KalkitsasYildiz KelahmetogluCynthia P. EstradaJemal TatarishviliDaniel HollLinda JanssonShervin BanitalebiMahmood Amiry-MoghaddamAurélie ErnstHagen B. HuttnerZaal KokaiaOlle LindvallLou BrundinJonas FrisénChristian GöritzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David O. Dias Jannis Kalkitsas Yildiz Kelahmetoglu Cynthia P. Estrada Jemal Tatarishvili Daniel Holl Linda Jansson Shervin Banitalebi Mahmood Amiry-Moghaddam Aurélie Ernst Hagen B. Huttner Zaal Kokaia Olle Lindvall Lou Brundin Jonas Frisén Christian Göritz Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
description	Fibrotic scar tissue limits central nervous system regeneration. Here, Dias et al. show that fibrotic scarring is common in mice and humans, following distinct lesions to the adult brain and spinal cord, and derives from a discrete population of GLAST-expressing perivascular cells.
format	article
author	David O. Dias Jannis Kalkitsas Yildiz Kelahmetoglu Cynthia P. Estrada Jemal Tatarishvili Daniel Holl Linda Jansson Shervin Banitalebi Mahmood Amiry-Moghaddam Aurélie Ernst Hagen B. Huttner Zaal Kokaia Olle Lindvall Lou Brundin Jonas Frisén Christian Göritz
author_facet	David O. Dias Jannis Kalkitsas Yildiz Kelahmetoglu Cynthia P. Estrada Jemal Tatarishvili Daniel Holl Linda Jansson Shervin Banitalebi Mahmood Amiry-Moghaddam Aurélie Ernst Hagen B. Huttner Zaal Kokaia Olle Lindvall Lou Brundin Jonas Frisén Christian Göritz
author_sort	David O. Dias
title	Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
title_short	Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
title_full	Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
title_fullStr	Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
title_full_unstemmed	Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
title_sort	pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b2cf5ecacb394539a29e9965db99ad35
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Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

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