EVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Respiratory muscle (RM) strength was studied in 85 men with exacerbations of chronic obstructive pulmonary disease (COPD). The strength indicators of expiratory (MEP) and inspiratory pressure (MIP, SNIP) in oral cavity were registered by means of the MicroRPM device (CareFusion, UK), as well as intr...

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Autores principales:	E. P. Kalinina, B. I. Geltser, I. G. Kurpatov, T. V. Gorborukova, T. A. Gvozdenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	chronic obstructive pulmonary disease respiratory muscles cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b2d1f2cbcbf14380b99cf41016b8bf57
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spelling	oai:doaj.org-article:b2d1f2cbcbf14380b99cf41016b8bf572021-11-18T08:03:48ZEVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE1563-06252313-741X10.15789/1563-0625-2019-3-487-494https://doaj.org/article/b2d1f2cbcbf14380b99cf41016b8bf572019-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1822https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XRespiratory muscle (RM) strength was studied in 85 men with exacerbations of chronic obstructive pulmonary disease (COPD). The strength indicators of expiratory (MEP) and inspiratory pressure (MIP, SNIP) in oral cavity were registered by means of the MicroRPM device (CareFusion, UK), as well as intranasal pressure levels by SNIP test. The measured MEP, MIP и SNIP values were compared to the proper indices. Serum concentrations of cytokines (IL-4, IL-6, IL-10, IL-17A, IL-21, TNFα, IFNγ and TGF-β) were determined. The results of the study were processed by means of canonical analysis and by clustering methods. Expiratory RM dysfunction was recorded in mild COPD, expiratory-inspiratory RM dysfunction was recorded in moderate COPD and the diaphragm dysfunction was recorded in severe COPD. Three groups of patients with different combinations of RM strength indicators and immune parameters were identified by means of cluster analysis. The cytokine profile in the first cluster was characterized by maximal concentrations of IL-17A, IL-21, TNFα and TGF-β, whereas RM strength indexes showed minimal values. In the second cluster, a decrease of RM strength indicators by 25-40% against control was associated with a sharp rise of IL-6, along with moderate increase of IL-21 and TGF-βconcentrations. In the third cluster, maximal levels of IL-6, IL-10 and IFNγwere registered, along with low levels of IL-17A, IL-21 and TGF-β concentrations, whereas MEP, MIP и SNIP values did not sufficiently differ from their levels in second cluster. The results of canonical and correlation analysis indicated to interconnections between either certain cytokines, or their pool with the RM strength indicators, dyspnea severity and functional state of COPD patients, thus suggesting involvement of cytokine-mediated mechanisms in pathogenesis of the respiratory muscle dysfunction.E. P. KalininaB. I. GeltserI. G. KurpatovT. V. GorborukovaT. A. GvozdenkoSPb RAACIarticlechronic obstructive pulmonary diseaserespiratory musclescytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 3, Pp 487-494 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic obstructive pulmonary disease respiratory muscles cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	chronic obstructive pulmonary disease respiratory muscles cytokines Immunologic diseases. Allergy RC581-607 E. P. Kalinina B. I. Geltser I. G. Kurpatov T. V. Gorborukova T. A. Gvozdenko EVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
description	Respiratory muscle (RM) strength was studied in 85 men with exacerbations of chronic obstructive pulmonary disease (COPD). The strength indicators of expiratory (MEP) and inspiratory pressure (MIP, SNIP) in oral cavity were registered by means of the MicroRPM device (CareFusion, UK), as well as intranasal pressure levels by SNIP test. The measured MEP, MIP и SNIP values were compared to the proper indices. Serum concentrations of cytokines (IL-4, IL-6, IL-10, IL-17A, IL-21, TNFα, IFNγ and TGF-β) were determined. The results of the study were processed by means of canonical analysis and by clustering methods. Expiratory RM dysfunction was recorded in mild COPD, expiratory-inspiratory RM dysfunction was recorded in moderate COPD and the diaphragm dysfunction was recorded in severe COPD. Three groups of patients with different combinations of RM strength indicators and immune parameters were identified by means of cluster analysis. The cytokine profile in the first cluster was characterized by maximal concentrations of IL-17A, IL-21, TNFα and TGF-β, whereas RM strength indexes showed minimal values. In the second cluster, a decrease of RM strength indicators by 25-40% against control was associated with a sharp rise of IL-6, along with moderate increase of IL-21 and TGF-βconcentrations. In the third cluster, maximal levels of IL-6, IL-10 and IFNγwere registered, along with low levels of IL-17A, IL-21 and TGF-β concentrations, whereas MEP, MIP и SNIP values did not sufficiently differ from their levels in second cluster. The results of canonical and correlation analysis indicated to interconnections between either certain cytokines, or their pool with the RM strength indicators, dyspnea severity and functional state of COPD patients, thus suggesting involvement of cytokine-mediated mechanisms in pathogenesis of the respiratory muscle dysfunction.
format	article
author	E. P. Kalinina B. I. Geltser I. G. Kurpatov T. V. Gorborukova T. A. Gvozdenko
author_facet	E. P. Kalinina B. I. Geltser I. G. Kurpatov T. V. Gorborukova T. A. Gvozdenko
author_sort	E. P. Kalinina
title	EVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_short	EVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_full	EVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_fullStr	EVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_full_unstemmed	EVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_sort	evaluation of cytokine-mediated mechanisms involved in development of respiratory muscle dysfunction in the patients with chronic obstructive pulmonary disease
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/b2d1f2cbcbf14380b99cf41016b8bf57
work_keys_str_mv	AT epkalinina evaluationofcytokinemediatedmechanismsinvolvedindevelopmentofrespiratorymuscledysfunctioninthepatientswithchronicobstructivepulmonarydisease AT bigeltser evaluationofcytokinemediatedmechanismsinvolvedindevelopmentofrespiratorymuscledysfunctioninthepatientswithchronicobstructivepulmonarydisease AT igkurpatov evaluationofcytokinemediatedmechanismsinvolvedindevelopmentofrespiratorymuscledysfunctioninthepatientswithchronicobstructivepulmonarydisease AT tvgorborukova evaluationofcytokinemediatedmechanismsinvolvedindevelopmentofrespiratorymuscledysfunctioninthepatientswithchronicobstructivepulmonarydisease AT tagvozdenko evaluationofcytokinemediatedmechanismsinvolvedindevelopmentofrespiratorymuscledysfunctioninthepatientswithchronicobstructivepulmonarydisease
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EVALUATION OF CYTOKINE-MEDIATED MECHANISMS INVOLVED IN DEVELOPMENT OF RESPIRATORY MUSCLE DYSFUNCTION IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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