Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques

High frequency semen exposure has been associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, Abdulhaqq et al. show that repeated vaginal exposure to semen reduces vaginal infection by SIV in non-human primates, and is associated with lower CCR5 expression in CD4 T-cell...

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Autores principales:	Shaheed A. Abdulhaqq, Melween Martinez, Guobin Kang, Idia V. Rodriguez, Stephanie M. Nichols, David Beaumont, Jocelin Joseph, Livio Azzoni, Xiangfan Yin, Megan Wise, David Weiner, Qin Liu, Andrea Foulkes, Jan Münch, Frank Kirchhoff, Christos Coutifaris, Georgia D. Tomaras, Carlos Sariol, Preston A. Marx, Qingsheng Li, Edmundo N. Kraiselburd, Luis J. Montaner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b2d4921ad0584927a32c97eaf6a0c1a2
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spelling	oai:doaj.org-article:b2d4921ad0584927a32c97eaf6a0c1a22021-12-02T16:57:45ZRepeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques10.1038/s41467-019-11814-52041-1723https://doaj.org/article/b2d4921ad0584927a32c97eaf6a0c1a22019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11814-5https://doaj.org/toc/2041-1723High frequency semen exposure has been associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, Abdulhaqq et al. show that repeated vaginal exposure to semen reduces vaginal infection by SIV in non-human primates, and is associated with lower CCR5 expression in CD4 T-cells and a local type-I interferon response.Shaheed A. AbdulhaqqMelween MartinezGuobin KangIdia V. RodriguezStephanie M. NicholsDavid BeaumontJocelin JosephLivio AzzoniXiangfan YinMegan WiseDavid WeinerQin LiuAndrea FoulkesJan MünchFrank KirchhoffChristos CoutifarisGeorgia D. TomarasCarlos SariolPreston A. MarxQingsheng LiEdmundo N. KraiselburdLuis J. MontanerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaheed A. Abdulhaqq Melween Martinez Guobin Kang Idia V. Rodriguez Stephanie M. Nichols David Beaumont Jocelin Joseph Livio Azzoni Xiangfan Yin Megan Wise David Weiner Qin Liu Andrea Foulkes Jan Münch Frank Kirchhoff Christos Coutifaris Georgia D. Tomaras Carlos Sariol Preston A. Marx Qingsheng Li Edmundo N. Kraiselburd Luis J. Montaner Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
description	High frequency semen exposure has been associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, Abdulhaqq et al. show that repeated vaginal exposure to semen reduces vaginal infection by SIV in non-human primates, and is associated with lower CCR5 expression in CD4 T-cells and a local type-I interferon response.
format	article
author	Shaheed A. Abdulhaqq Melween Martinez Guobin Kang Idia V. Rodriguez Stephanie M. Nichols David Beaumont Jocelin Joseph Livio Azzoni Xiangfan Yin Megan Wise David Weiner Qin Liu Andrea Foulkes Jan Münch Frank Kirchhoff Christos Coutifaris Georgia D. Tomaras Carlos Sariol Preston A. Marx Qingsheng Li Edmundo N. Kraiselburd Luis J. Montaner
author_facet	Shaheed A. Abdulhaqq Melween Martinez Guobin Kang Idia V. Rodriguez Stephanie M. Nichols David Beaumont Jocelin Joseph Livio Azzoni Xiangfan Yin Megan Wise David Weiner Qin Liu Andrea Foulkes Jan Münch Frank Kirchhoff Christos Coutifaris Georgia D. Tomaras Carlos Sariol Preston A. Marx Qingsheng Li Edmundo N. Kraiselburd Luis J. Montaner
author_sort	Shaheed A. Abdulhaqq
title	Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
title_short	Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
title_full	Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
title_fullStr	Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
title_full_unstemmed	Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
title_sort	repeated semen exposure decreases cervicovaginal sivmac251 infection in rhesus macaques
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b2d4921ad0584927a32c97eaf6a0c1a2
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Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques

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