Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation

Shuwen Yue,1,* Ning Xue,2,* Honglei Li,3 Zhen Chen,1 Baosheng Huang,4 Xing Wang1 1Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Department of Acupuncture, Jurong Hospital Affiliated to Jiangsu University, Zhenjiang, P...

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Autores principales:	Yue S, Xue N, Li H, Chen Z, Huang B, Wang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	isomangiferin renal injury inflammation hmgb1/nlrp3/nf-κb diabetics Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b2d59cc89d7048608ae5e019e47e387a
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spelling	oai:doaj.org-article:b2d59cc89d7048608ae5e019e47e387a2021-12-02T11:10:22ZIsomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation1178-7007https://doaj.org/article/b2d59cc89d7048608ae5e019e47e387a2020-11-01T00:00:00Zhttps://www.dovepress.com/isomangiferin-attenuates-renal-injury-in-diabetic-mice-via-inhibiting--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Shuwen Yue,1,* Ning Xue,2,* Honglei Li,3 Zhen Chen,1 Baosheng Huang,4 Xing Wang1 1Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Department of Acupuncture, Jurong Hospital Affiliated to Jiangsu University, Zhenjiang, People’s Republic of China; 3Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang, People’s Republic of China; 4Department of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xing WangChina Pharmaceutical University, Nanjing, Jiangsu 211199, People’s Republic of ChinaEmail star10000@sina.comBaosheng HuangSir Run Run Hospital, Nanjing Medical University, No. 101, Longmiandadao, Jiangning District, Nanjing, Jiangsu 211166, People’s Republic of ChinaEmail labskcpu@sina.comAim: Renal injury induced by diabetes is reported to be associated with inflammation. Isomangiferin (ISO), a xanthone C-glucoside from the Cyclopia subfamily, exhibits many pharmacological properties. This study aimed to evaluate the protection of ISO against renal damage in diabetic mice.Methods: Serum glucose, insulin, uric acid, creatinine, total cholesterol (TC), triglyceride (TG), and inflammatory cytokines in serum and the kidney of db/db diabetes model mice were detected. The components of high mobility group protein B1 (HMGB1)/NACHT leucine-rich repeat- and PYD-containing 3 (NLRP3)/nuclear factor kappa-B (NF-κB) pathway in the kidney were detected by Western blot and immunohistochemical analysis.Results: ISO improved lipid profile and glucose tolerance, and inhibited the production of inflammatory cytokines in a db/db model mice. Moreover, ISO decreased biochemical indexes in the serum and inhibited the activation of HMGB1/NLRP3/NF-κB signaling in the kidney of db/db model mice.Conclusion: ISO provides protection against renal injury via inhibiting HMGB1/NLRP3/NF-κB signaling in a diabetic mouse model.Keywords: isomangiferin, renal injury, inflammation, HMGB1/NLRP3/NF-κB, diabeticsYue SXue NLi HChen ZHuang BWang XDove Medical Pressarticleisomangiferinrenal injuryinflammationhmgb1/nlrp3/nf-κbdiabeticsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4273-4280 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	isomangiferin renal injury inflammation hmgb1/nlrp3/nf-κb diabetics Specialties of internal medicine RC581-951
spellingShingle	isomangiferin renal injury inflammation hmgb1/nlrp3/nf-κb diabetics Specialties of internal medicine RC581-951 Yue S Xue N Li H Chen Z Huang B Wang X Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation
description	Shuwen Yue,1,* Ning Xue,2,* Honglei Li,3 Zhen Chen,1 Baosheng Huang,4 Xing Wang1 1Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Department of Acupuncture, Jurong Hospital Affiliated to Jiangsu University, Zhenjiang, People’s Republic of China; 3Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang, People’s Republic of China; 4Department of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xing WangChina Pharmaceutical University, Nanjing, Jiangsu 211199, People’s Republic of ChinaEmail star10000@sina.comBaosheng HuangSir Run Run Hospital, Nanjing Medical University, No. 101, Longmiandadao, Jiangning District, Nanjing, Jiangsu 211166, People’s Republic of ChinaEmail labskcpu@sina.comAim: Renal injury induced by diabetes is reported to be associated with inflammation. Isomangiferin (ISO), a xanthone C-glucoside from the Cyclopia subfamily, exhibits many pharmacological properties. This study aimed to evaluate the protection of ISO against renal damage in diabetic mice.Methods: Serum glucose, insulin, uric acid, creatinine, total cholesterol (TC), triglyceride (TG), and inflammatory cytokines in serum and the kidney of db/db diabetes model mice were detected. The components of high mobility group protein B1 (HMGB1)/NACHT leucine-rich repeat- and PYD-containing 3 (NLRP3)/nuclear factor kappa-B (NF-κB) pathway in the kidney were detected by Western blot and immunohistochemical analysis.Results: ISO improved lipid profile and glucose tolerance, and inhibited the production of inflammatory cytokines in a db/db model mice. Moreover, ISO decreased biochemical indexes in the serum and inhibited the activation of HMGB1/NLRP3/NF-κB signaling in the kidney of db/db model mice.Conclusion: ISO provides protection against renal injury via inhibiting HMGB1/NLRP3/NF-κB signaling in a diabetic mouse model.Keywords: isomangiferin, renal injury, inflammation, HMGB1/NLRP3/NF-κB, diabetics
format	article
author	Yue S Xue N Li H Chen Z Huang B Wang X
author_facet	Yue S Xue N Li H Chen Z Huang B Wang X
author_sort	Yue S
title	Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation
title_short	Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation
title_full	Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation
title_fullStr	Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation
title_full_unstemmed	Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation
title_sort	isomangiferin attenuates renal injury in diabetic mice via inhibiting inflammation
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b2d59cc89d7048608ae5e019e47e387a
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Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation

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