Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.
<h4>Purpose</h4>The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease.<h4>Methods</h4>We conducted a study of 309 in...
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| Auteurs principaux: | , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2012
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/b2d8ee92bc5d4973856f7f6fe9fb1e9f |
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| Résumé: | <h4>Purpose</h4>The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease.<h4>Methods</h4>We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology.<h4>Results</h4>We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations.<h4>Conclusions</h4>Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability. |
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