Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.

<h4>Purpose</h4>The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease.<h4>Methods</h4>We conducted a study of 309 in...

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Autores principales:	Raquel Catarino, Ana Coelho, António Araújo, Mónica Gomes, Augusto Nogueira, Carlos Lopes, Rui Medeiros
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b2d8ee92bc5d4973856f7f6fe9fb1e9f
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spelling	oai:doaj.org-article:b2d8ee92bc5d4973856f7f6fe9fb1e9f2021-11-18T07:15:46ZCirculating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.1932-620310.1371/journal.pone.0038559https://doaj.org/article/b2d8ee92bc5d4973856f7f6fe9fb1e9f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22701665/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease.<h4>Methods</h4>We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology.<h4>Results</h4>We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations.<h4>Conclusions</h4>Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.Raquel CatarinoAna CoelhoAntónio AraújoMónica GomesAugusto NogueiraCarlos LopesRui MedeirosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e38559 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Raquel Catarino Ana Coelho António Araújo Mónica Gomes Augusto Nogueira Carlos Lopes Rui Medeiros Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.
description	<h4>Purpose</h4>The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease.<h4>Methods</h4>We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology.<h4>Results</h4>We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations.<h4>Conclusions</h4>Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.
format	article
author	Raquel Catarino Ana Coelho António Araújo Mónica Gomes Augusto Nogueira Carlos Lopes Rui Medeiros
author_facet	Raquel Catarino Ana Coelho António Araújo Mónica Gomes Augusto Nogueira Carlos Lopes Rui Medeiros
author_sort	Raquel Catarino
title	Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.
title_short	Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.
title_full	Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.
title_fullStr	Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.
title_full_unstemmed	Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.
title_sort	circulating dna: diagnostic tool and predictive marker for overall survival of nsclc patients.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b2d8ee92bc5d4973856f7f6fe9fb1e9f
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Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.

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