Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma

Abstract Background Brain metastases (BM) from esophageal carcinoma (EC) is clinically rare and has not yet been reported in elderly patients. This study aimed to investigate the clinicopathological characteristics, outcomes and prognostic factors of BM in elderly patients with EC, in order to provi...

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Autores principales:	Yi Wang, Linlin Xiao, Jiandong Zhang, Xiaoyan Lv, Feng Cao, Min Zhao, Fengpeng Wu, Shaowu Jing, Jun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	brain metastases elderly patients esophageal carcinoma prognosis radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b2da3f3c8f8c4bbbb5dc85324e9c29fe
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spelling	oai:doaj.org-article:b2da3f3c8f8c4bbbb5dc85324e9c29fe2021-11-14T23:28:25ZClinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma1759-77141759-770610.1111/1759-7714.14167https://doaj.org/article/b2da3f3c8f8c4bbbb5dc85324e9c29fe2021-11-01T00:00:00Zhttps://doi.org/10.1111/1759-7714.14167https://doaj.org/toc/1759-7706https://doaj.org/toc/1759-7714Abstract Background Brain metastases (BM) from esophageal carcinoma (EC) is clinically rare and has not yet been reported in elderly patients. This study aimed to investigate the clinicopathological characteristics, outcomes and prognostic factors of BM in elderly patients with EC, in order to provide guidance for clinical practice. Methods A total of 20 EC patients older than 65 years who were diagnosed with BM were identified from the fourth Hospital of Hebei Medical University between January 1, 2009 and December 31, 2018. Survival was evaluated by the Kaplan–Meier method and Cox proportional hazards models. Results The median time from diagnosis of EC to BM was 11.8 months (0–249.2 months). The median overall survival (OS) was 4.8 months (1.13–23.3 months), with 20% of patients achieving the 1‐year survival rate. Patients with KPS score of ≥70 had a significantly better OS than those with KPS score<70 (8.4 vs. 3.9 months, p = 0.033). Compared to patients without brain radiotherapy, patients with brain radiotherapy showed better outcomes in both median OS (8.4 vs. 2.9 months) and 1‐year survival rate (23.1% vs. 14.3%, p = 0.043). The median OS of patients with radiotherapy combined with chemotherapy and/or targeted therapy and radiotherapy alone was 9.7 months (3.4–23.3 months) and 7.2 months (1.7–18.4 months), respectively, with no significant difference between the two groups (p = 0.215). Conclusions Brain radiotherapy provided clinically meaningful survival benefit for elderly patients with BM from EC. Thus, active treatments for those patients might be required.Yi WangLinlin XiaoJiandong ZhangXiaoyan LvFeng CaoMin ZhaoFengpeng WuShaowu JingJun WangWileyarticlebrain metastaseselderly patientsesophageal carcinomaprognosisradiotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENThoracic Cancer, Vol 12, Iss 22, Pp 3005-3010 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain metastases elderly patients esophageal carcinoma prognosis radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	brain metastases elderly patients esophageal carcinoma prognosis radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yi Wang Linlin Xiao Jiandong Zhang Xiaoyan Lv Feng Cao Min Zhao Fengpeng Wu Shaowu Jing Jun Wang Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma
description	Abstract Background Brain metastases (BM) from esophageal carcinoma (EC) is clinically rare and has not yet been reported in elderly patients. This study aimed to investigate the clinicopathological characteristics, outcomes and prognostic factors of BM in elderly patients with EC, in order to provide guidance for clinical practice. Methods A total of 20 EC patients older than 65 years who were diagnosed with BM were identified from the fourth Hospital of Hebei Medical University between January 1, 2009 and December 31, 2018. Survival was evaluated by the Kaplan–Meier method and Cox proportional hazards models. Results The median time from diagnosis of EC to BM was 11.8 months (0–249.2 months). The median overall survival (OS) was 4.8 months (1.13–23.3 months), with 20% of patients achieving the 1‐year survival rate. Patients with KPS score of ≥70 had a significantly better OS than those with KPS score<70 (8.4 vs. 3.9 months, p = 0.033). Compared to patients without brain radiotherapy, patients with brain radiotherapy showed better outcomes in both median OS (8.4 vs. 2.9 months) and 1‐year survival rate (23.1% vs. 14.3%, p = 0.043). The median OS of patients with radiotherapy combined with chemotherapy and/or targeted therapy and radiotherapy alone was 9.7 months (3.4–23.3 months) and 7.2 months (1.7–18.4 months), respectively, with no significant difference between the two groups (p = 0.215). Conclusions Brain radiotherapy provided clinically meaningful survival benefit for elderly patients with BM from EC. Thus, active treatments for those patients might be required.
format	article
author	Yi Wang Linlin Xiao Jiandong Zhang Xiaoyan Lv Feng Cao Min Zhao Fengpeng Wu Shaowu Jing Jun Wang
author_facet	Yi Wang Linlin Xiao Jiandong Zhang Xiaoyan Lv Feng Cao Min Zhao Fengpeng Wu Shaowu Jing Jun Wang
author_sort	Yi Wang
title	Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma
title_short	Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma
title_full	Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma
title_fullStr	Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma
title_full_unstemmed	Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma
title_sort	clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/b2da3f3c8f8c4bbbb5dc85324e9c29fe
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_version_	1718429005205471232

Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma

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