The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications

Multiple myeloma (MM) is a genetically complex disease that results from a multistep transformation of normal to malignant plasma cells in the bone marrow. However, the molecular mechanisms responsible for the initiation and heterogeneous evolution of MM remain largely unknown. A fundamental step ne...

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Autores principales:	Anna Puła, Paweł Robak, Damian Mikulski, Tadeusz Robak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biology drug resistance gene expression profiling mRNA multiple myeloma prognosis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b2dd11d1d39046649e62441a9ec913f4
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id	oai:doaj.org-article:b2dd11d1d39046649e62441a9ec913f4
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spelling	oai:doaj.org-article:b2dd11d1d39046649e62441a9ec913f42021-11-11T17:27:59ZThe Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications10.3390/ijms2221120701422-00671661-6596https://doaj.org/article/b2dd11d1d39046649e62441a9ec913f42021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12070https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Multiple myeloma (MM) is a genetically complex disease that results from a multistep transformation of normal to malignant plasma cells in the bone marrow. However, the molecular mechanisms responsible for the initiation and heterogeneous evolution of MM remain largely unknown. A fundamental step needed to understand the oncogenesis of MM and its response to therapy is the identification of driver mutations. The introduction of gene expression profiling (GEP) in MM is an important step in elucidating the molecular heterogeneity of MM and its clinical relevance. Since some mutations in myeloma occur in non-coding regions, studies based on the analysis of mRNA provide more comprehensive information on the oncogenic pathways and mechanisms relevant to MM biology. In this review, we discuss the role of gene expression profiling in understanding the biology of multiple myeloma together with the clinical manifestation of the disease, as well as its impact on treatment decisions and future directions.Anna PułaPaweł RobakDamian MikulskiTadeusz RobakMDPI AGarticlebiologydrug resistancegene expression profilingmRNAmultiple myelomaprognosisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12070, p 12070 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biology drug resistance gene expression profiling mRNA multiple myeloma prognosis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	biology drug resistance gene expression profiling mRNA multiple myeloma prognosis Biology (General) QH301-705.5 Chemistry QD1-999 Anna Puła Paweł Robak Damian Mikulski Tadeusz Robak The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications
description	Multiple myeloma (MM) is a genetically complex disease that results from a multistep transformation of normal to malignant plasma cells in the bone marrow. However, the molecular mechanisms responsible for the initiation and heterogeneous evolution of MM remain largely unknown. A fundamental step needed to understand the oncogenesis of MM and its response to therapy is the identification of driver mutations. The introduction of gene expression profiling (GEP) in MM is an important step in elucidating the molecular heterogeneity of MM and its clinical relevance. Since some mutations in myeloma occur in non-coding regions, studies based on the analysis of mRNA provide more comprehensive information on the oncogenic pathways and mechanisms relevant to MM biology. In this review, we discuss the role of gene expression profiling in understanding the biology of multiple myeloma together with the clinical manifestation of the disease, as well as its impact on treatment decisions and future directions.
format	article
author	Anna Puła Paweł Robak Damian Mikulski Tadeusz Robak
author_facet	Anna Puła Paweł Robak Damian Mikulski Tadeusz Robak
author_sort	Anna Puła
title	The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications
title_short	The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications
title_full	The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications
title_fullStr	The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications
title_full_unstemmed	The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications
title_sort	significance of mrna in the biology of multiple myeloma and its clinical implications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b2dd11d1d39046649e62441a9ec913f4
work_keys_str_mv	AT annapuła thesignificanceofmrnainthebiologyofmultiplemyelomaanditsclinicalimplications AT pawełrobak thesignificanceofmrnainthebiologyofmultiplemyelomaanditsclinicalimplications AT damianmikulski thesignificanceofmrnainthebiologyofmultiplemyelomaanditsclinicalimplications AT tadeuszrobak thesignificanceofmrnainthebiologyofmultiplemyelomaanditsclinicalimplications AT annapuła significanceofmrnainthebiologyofmultiplemyelomaanditsclinicalimplications AT pawełrobak significanceofmrnainthebiologyofmultiplemyelomaanditsclinicalimplications AT damianmikulski significanceofmrnainthebiologyofmultiplemyelomaanditsclinicalimplications AT tadeuszrobak significanceofmrnainthebiologyofmultiplemyelomaanditsclinicalimplications
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The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications

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