PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats

Abstract Manual acupuncture (MA) can be used to manage high blood pressure; however, the underlying molecular mechanism remains unknown. To explore the mechanism of acupuncture in the treatment of hypertension, Wistar Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) were subjected to eit...

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Autores principales:	Jing Li, Chong Peng, Dongjian Lai, Yajing Fang, Daihong Luo, Zunming Zhou, Chenyun Li, Xinsheng Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b2df4e9551984102bece9ff374f9349c
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spelling	oai:doaj.org-article:b2df4e9551984102bece9ff374f9349c2021-12-02T14:49:18ZPET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats10.1038/s41598-021-90467-12045-2322https://doaj.org/article/b2df4e9551984102bece9ff374f9349c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90467-1https://doaj.org/toc/2045-2322Abstract Manual acupuncture (MA) can be used to manage high blood pressure; however, the underlying molecular mechanism remains unknown. To explore the mechanism of acupuncture in the treatment of hypertension, Wistar Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) were subjected to either MA stimulation or the corresponding sham procedure as a negative control (Sham-MA) for 1 week. PET-CT scans, transcriptomics and molecular biology were used to evaluate the effect of MA. The results show that MA can regulate blood pressure in SHRs, change the glucose metabolism of the paraventricular hypothalamus (PVH), and affect the mRNA and protein expression levels of differentially expressed genes in the PVH. These genes may lower blood pressure by regulating angiotensin, endothelial function and inflammation. These findings reveal that MA regulates multiple biological processes and genes/proteins of the PVH, and provide a solid theoretical basis for exploring the mechanisms by which MA regulates hypertension.Jing LiChong PengDongjian LaiYajing FangDaihong LuoZunming ZhouChenyun LiXinsheng LaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Li Chong Peng Dongjian Lai Yajing Fang Daihong Luo Zunming Zhou Chenyun Li Xinsheng Lai PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats
description	Abstract Manual acupuncture (MA) can be used to manage high blood pressure; however, the underlying molecular mechanism remains unknown. To explore the mechanism of acupuncture in the treatment of hypertension, Wistar Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) were subjected to either MA stimulation or the corresponding sham procedure as a negative control (Sham-MA) for 1 week. PET-CT scans, transcriptomics and molecular biology were used to evaluate the effect of MA. The results show that MA can regulate blood pressure in SHRs, change the glucose metabolism of the paraventricular hypothalamus (PVH), and affect the mRNA and protein expression levels of differentially expressed genes in the PVH. These genes may lower blood pressure by regulating angiotensin, endothelial function and inflammation. These findings reveal that MA regulates multiple biological processes and genes/proteins of the PVH, and provide a solid theoretical basis for exploring the mechanisms by which MA regulates hypertension.
format	article
author	Jing Li Chong Peng Dongjian Lai Yajing Fang Daihong Luo Zunming Zhou Chenyun Li Xinsheng Lai
author_facet	Jing Li Chong Peng Dongjian Lai Yajing Fang Daihong Luo Zunming Zhou Chenyun Li Xinsheng Lai
author_sort	Jing Li
title	PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats
title_short	PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats
title_full	PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats
title_fullStr	PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats
title_full_unstemmed	PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats
title_sort	pet-ct and rna sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b2df4e9551984102bece9ff374f9349c
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PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats

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