EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA
Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR. In patients with bronchial asthma, (ABA and NABA) we determ...
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| Auteurs principaux: | , , , , , |
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| Format: | article |
| Langue: | RU |
| Publié: |
SPb RAACI
2016
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| Accès en ligne: | https://doaj.org/article/b2e0609efee8404b914df3d33d24c443 |
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| Résumé: | Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR. In patients with bronchial asthma, (ABA and NABA) we determined a significant increase of mRNA expression levels for a SOCS5 negative transcription regulator in peripheral blood mononuclears, in comparison with control group. Thus, an increase of SOCS5-expression, and of the SOCS3 mRNA expression in patients with BA may be associated with protective anti-inflammatory response. |
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