EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA

Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR. In patients with bronchial asthma, (ABA and NABA) we determ...

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Autores principales:	V. V. Lim, V. A. Ivanov, L. N. Sorokina, V. N. Mineev, M. A. Nyoma, V. I. Trofimov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	bronchial asthma socs-proteins socs3 socs5 mononuclear blood cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b2e0609efee8404b914df3d33d24c443
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spelling	oai:doaj.org-article:b2e0609efee8404b914df3d33d24c4432021-11-18T08:03:45ZEXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2016-5-451-458https://doaj.org/article/b2e0609efee8404b914df3d33d24c4432016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1069https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR. In patients with bronchial asthma, (ABA and NABA) we determined a significant increase of mRNA expression levels for a SOCS5 negative transcription regulator in peripheral blood mononuclears, in comparison with control group. Thus, an increase of SOCS5-expression, and of the SOCS3 mRNA expression in patients with BA may be associated with protective anti-inflammatory response.V. V. LimV. A. IvanovL. N. SorokinaV. N. MineevM. A. NyomaV. I. TrofimovSPb RAACIarticlebronchial asthmasocs-proteinssocs3socs5mononuclear blood cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 5, Pp 451-458 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma socs-proteins socs3 socs5 mononuclear blood cells Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma socs-proteins socs3 socs5 mononuclear blood cells Immunologic diseases. Allergy RC581-607 V. V. Lim V. A. Ivanov L. N. Sorokina V. N. Mineev M. A. Nyoma V. I. Trofimov EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA
description	Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR. In patients with bronchial asthma, (ABA and NABA) we determined a significant increase of mRNA expression levels for a SOCS5 negative transcription regulator in peripheral blood mononuclears, in comparison with control group. Thus, an increase of SOCS5-expression, and of the SOCS3 mRNA expression in patients with BA may be associated with protective anti-inflammatory response.
format	article
author	V. V. Lim V. A. Ivanov L. N. Sorokina V. N. Mineev M. A. Nyoma V. I. Trofimov
author_facet	V. V. Lim V. A. Ivanov L. N. Sorokina V. N. Mineev M. A. Nyoma V. I. Trofimov
author_sort	V. V. Lim
title	EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA
title_short	EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA
title_full	EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA
title_fullStr	EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA
title_full_unstemmed	EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA
title_sort	expression of negative transcription regulators in peripheral blood mononuclears in patients with bronchial asthma
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/b2e0609efee8404b914df3d33d24c443
work_keys_str_mv	AT vvlim expressionofnegativetranscriptionregulatorsinperipheralbloodmononuclearsinpatientswithbronchialasthma AT vaivanov expressionofnegativetranscriptionregulatorsinperipheralbloodmononuclearsinpatientswithbronchialasthma AT lnsorokina expressionofnegativetranscriptionregulatorsinperipheralbloodmononuclearsinpatientswithbronchialasthma AT vnmineev expressionofnegativetranscriptionregulatorsinperipheralbloodmononuclearsinpatientswithbronchialasthma AT manyoma expressionofnegativetranscriptionregulatorsinperipheralbloodmononuclearsinpatientswithbronchialasthma AT vitrofimov expressionofnegativetranscriptionregulatorsinperipheralbloodmononuclearsinpatientswithbronchialasthma
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EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA

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