Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.

Ephrins and Eph receptors are involved in the establishment of vertebrate tissue boundaries. The complexity of the system is puzzling, however in many instances, tissues express multiple ephrins and Ephs on both sides of the boundary, a situation that should in principle cause repulsion between cell...

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Autores principales: Nazanin Rohani, Andrea Parmeggiani, Rudolf Winklbauer, François Fagotto
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Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/b2ef38711e73473db14e90025c6a6177
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spelling oai:doaj.org-article:b2ef38711e73473db14e90025c6a61772021-11-25T05:32:57ZVariable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.1544-91731545-788510.1371/journal.pbio.1001955https://doaj.org/article/b2ef38711e73473db14e90025c6a61772014-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.1001955https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Ephrins and Eph receptors are involved in the establishment of vertebrate tissue boundaries. The complexity of the system is puzzling, however in many instances, tissues express multiple ephrins and Ephs on both sides of the boundary, a situation that should in principle cause repulsion between cells within each tissue. Although co-expression of ephrins and Eph receptors is widespread in embryonic tissues, neurons, and cancer cells, it is still unresolved how the respective signals are integrated into a coherent output. We present a simple explanation for the confinement of repulsion to the tissue interface: Using the dorsal ectoderm-mesoderm boundary of the Xenopus embryo as a model, we identify selective functional interactions between ephrin-Eph pairs that are expressed in partial complementary patterns. The combined repulsive signals add up to be strongest across the boundary, where they reach sufficient intensity to trigger cell detachments. The process can be largely explained using a simple model based exclusively on relative ephrin and Eph concentrations and binding affinities. We generalize these findings for the ventral ectoderm-mesoderm boundary and the notochord boundary, both of which appear to function on the same principles. These results provide a paradigm for how developmental systems may integrate multiple cues to generate discrete local outcomes.Nazanin RohaniAndrea ParmeggianiRudolf WinklbauerFrançois FagottoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 12, Iss 9, p e1001955 (2014)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Nazanin Rohani
Andrea Parmeggiani
Rudolf Winklbauer
François Fagotto
Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.
description Ephrins and Eph receptors are involved in the establishment of vertebrate tissue boundaries. The complexity of the system is puzzling, however in many instances, tissues express multiple ephrins and Ephs on both sides of the boundary, a situation that should in principle cause repulsion between cells within each tissue. Although co-expression of ephrins and Eph receptors is widespread in embryonic tissues, neurons, and cancer cells, it is still unresolved how the respective signals are integrated into a coherent output. We present a simple explanation for the confinement of repulsion to the tissue interface: Using the dorsal ectoderm-mesoderm boundary of the Xenopus embryo as a model, we identify selective functional interactions between ephrin-Eph pairs that are expressed in partial complementary patterns. The combined repulsive signals add up to be strongest across the boundary, where they reach sufficient intensity to trigger cell detachments. The process can be largely explained using a simple model based exclusively on relative ephrin and Eph concentrations and binding affinities. We generalize these findings for the ventral ectoderm-mesoderm boundary and the notochord boundary, both of which appear to function on the same principles. These results provide a paradigm for how developmental systems may integrate multiple cues to generate discrete local outcomes.
format article
author Nazanin Rohani
Andrea Parmeggiani
Rudolf Winklbauer
François Fagotto
author_facet Nazanin Rohani
Andrea Parmeggiani
Rudolf Winklbauer
François Fagotto
author_sort Nazanin Rohani
title Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.
title_short Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.
title_full Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.
title_fullStr Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.
title_full_unstemmed Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.
title_sort variable combinations of specific ephrin ligand/eph receptor pairs control embryonic tissue separation.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/b2ef38711e73473db14e90025c6a6177
work_keys_str_mv AT nazaninrohani variablecombinationsofspecificephrinligandephreceptorpairscontrolembryonictissueseparation
AT andreaparmeggiani variablecombinationsofspecificephrinligandephreceptorpairscontrolembryonictissueseparation
AT rudolfwinklbauer variablecombinationsofspecificephrinligandephreceptorpairscontrolembryonictissueseparation
AT francoisfagotto variablecombinationsofspecificephrinligandephreceptorpairscontrolembryonictissueseparation
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