Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks

Glutamatergic neurons in the mammalian cortex are born from a heterogeneous pool of embryonic progenitors, however, it is unclear how these different progenitors contribute to diversity within the mature cortex. In this study, authors combine in utero progenitor labeling techniques with targeted Pat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tommas J. Ellender, Sophie V. Avery, Kashif Mahfooz, Jakub Scaber, Alexander von Klemperer, Sophie L. Nixon, Matthew J. Buchan, Joram J. van Rheede, Aleksandra Gatti, Cameron Waites, Hania J. Pavlou, David Sims, Sarah E. Newey, Colin J. Akerman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b2efc70c3ecc4ecdb9771cc841cd4f43
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b2efc70c3ecc4ecdb9771cc841cd4f43
record_format	dspace
spelling	oai:doaj.org-article:b2efc70c3ecc4ecdb9771cc841cd4f432021-12-02T16:57:08ZEmbryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks10.1038/s41467-019-13206-12041-1723https://doaj.org/article/b2efc70c3ecc4ecdb9771cc841cd4f432019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13206-1https://doaj.org/toc/2041-1723Glutamatergic neurons in the mammalian cortex are born from a heterogeneous pool of embryonic progenitors, however, it is unclear how these different progenitors contribute to diversity within the mature cortex. In this study, authors combine in utero progenitor labeling techniques with targeted Patch-Seq methods and high resolution synaptic circuit mapping in the mature mouse cortex to show that intermediate progenitors can generate restricted sets of transcriptomically-defined glutamatergic neurons that have distinct patterns of local and long-range synaptic connections.Tommas J. EllenderSophie V. AveryKashif MahfoozJakub ScaberAlexander von KlempererSophie L. NixonMatthew J. BuchanJoram J. van RheedeAleksandra GattiCameron WaitesHania J. PavlouDavid SimsSarah E. NeweyColin J. AkermanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tommas J. Ellender Sophie V. Avery Kashif Mahfooz Jakub Scaber Alexander von Klemperer Sophie L. Nixon Matthew J. Buchan Joram J. van Rheede Aleksandra Gatti Cameron Waites Hania J. Pavlou David Sims Sarah E. Newey Colin J. Akerman Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks
description	Glutamatergic neurons in the mammalian cortex are born from a heterogeneous pool of embryonic progenitors, however, it is unclear how these different progenitors contribute to diversity within the mature cortex. In this study, authors combine in utero progenitor labeling techniques with targeted Patch-Seq methods and high resolution synaptic circuit mapping in the mature mouse cortex to show that intermediate progenitors can generate restricted sets of transcriptomically-defined glutamatergic neurons that have distinct patterns of local and long-range synaptic connections.
format	article
author	Tommas J. Ellender Sophie V. Avery Kashif Mahfooz Jakub Scaber Alexander von Klemperer Sophie L. Nixon Matthew J. Buchan Joram J. van Rheede Aleksandra Gatti Cameron Waites Hania J. Pavlou David Sims Sarah E. Newey Colin J. Akerman
author_facet	Tommas J. Ellender Sophie V. Avery Kashif Mahfooz Jakub Scaber Alexander von Klemperer Sophie L. Nixon Matthew J. Buchan Joram J. van Rheede Aleksandra Gatti Cameron Waites Hania J. Pavlou David Sims Sarah E. Newey Colin J. Akerman
author_sort	Tommas J. Ellender
title	Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks
title_short	Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks
title_full	Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks
title_fullStr	Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks
title_full_unstemmed	Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks
title_sort	embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b2efc70c3ecc4ecdb9771cc841cd4f43
work_keys_str_mv	AT tommasjellender embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT sophievavery embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT kashifmahfooz embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT jakubscaber embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT alexandervonklemperer embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT sophielnixon embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT matthewjbuchan embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT joramjvanrheede embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT aleksandragatti embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT cameronwaites embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT haniajpavlou embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT davidsims embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT sarahenewey embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks AT colinjakerman embryonicprogenitorpoolsgeneratediversityinfinescaleexcitatorycorticalsubnetworks
_version_	1718382642909413376

Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks

Ejemplares similares