Metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study

Henriette Thisted Horsdal,1,2 Michael Eriksen Benros,2,3 Ole Köhler-Forsberg,2–4 Jesper Krogh,3 Christiane Gasse1,2,5 1National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus BSS, Aarhus University, Aarhus, 2The Lundbeck Foundation Init...

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Autores principales:	Horsdal HT, Benros ME, Köhler-Forsberg O, Krogh J, Gasse C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Schizophrenia metabolism epidemiology lipids glucose Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b2f43decd3394a1f9b117cb930f458fd
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spelling	oai:doaj.org-article:b2f43decd3394a1f9b117cb930f458fd2021-12-02T02:07:50ZMetabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study1178-2021https://doaj.org/article/b2f43decd3394a1f9b117cb930f458fd2017-02-01T00:00:00Zhttps://www.dovepress.com/metabolic-profile-at-first-time-schizophrenia-diagnosis-a-population-b-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Henriette Thisted Horsdal,1,2 Michael Eriksen Benros,2,3 Ole Köhler-Forsberg,2–4 Jesper Krogh,3 Christiane Gasse1,2,5 1National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus BSS, Aarhus University, Aarhus, 2The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, 3Faculty of Health Sciences, Mental Health Centre Copenhagen, University of Copenhagen, Copenhagen, 4Psychosis Research Unit, Aarhus University Hospital, Risskov, 5Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark Objective: Schizophrenia and/or antipsychotic drug use are associated with metabolic abnormalities; however, knowledge regarding metabolic status and physician’s monitoring of metabolic status at first schizophrenia diagnosis is sparse. We assessed the prevalence of monitoring for metabolic blood abnormalities and characterized the metabolic profiles in people with a first-time schizophrenia diagnosis. Methods: This is a population-based cross-sectional study including all adults born in Denmark after January 1, 1955, with their first schizophrenia diagnosis between 2000 and 2012 in the Central Denmark Region. Information on metabolic parameters was obtained from a clinical laboratory information system. Associations were calculated using Wilcoxon rank-sum tests, chi-square tests, logistic regression, and Spearman’s correlation coefficients. Results: A total of 2,452 people with a first-time schizophrenia diagnosis were identified, of whom 1,040 (42.4%) were monitored for metabolic abnormalities. Among those monitored, 58.4% had an abnormal lipid profile and 13.8% had an abnormal glucose profile. People who had previously filled prescription(s) for antipsychotic drugs were more likely to present an abnormal lipid measure (65.7% vs 46.8%, P<0.001) and abnormal glucose profile (16.4% vs 10.1%, P=0.01). Conclusion: Metabolic abnormalities are common at first schizophrenia diagnosis, particularly among those with previous antipsychotic prescription(s). Increased metabolic abnormalities already present in the early phase of schizophrenia emphasize the need for increased monitoring and management. Keywords: schizophrenia, metabolism, epidemiology, lipids, glucoseHorsdal HTBenros MEKöhler-Forsberg OKrogh JGasse CDove Medical PressarticleSchizophreniametabolismepidemiologylipidsglucoseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 621-630 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schizophrenia metabolism epidemiology lipids glucose Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Schizophrenia metabolism epidemiology lipids glucose Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Horsdal HT Benros ME Köhler-Forsberg O Krogh J Gasse C Metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study
description	Henriette Thisted Horsdal,1,2 Michael Eriksen Benros,2,3 Ole Köhler-Forsberg,2–4 Jesper Krogh,3 Christiane Gasse1,2,5 1National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus BSS, Aarhus University, Aarhus, 2The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, 3Faculty of Health Sciences, Mental Health Centre Copenhagen, University of Copenhagen, Copenhagen, 4Psychosis Research Unit, Aarhus University Hospital, Risskov, 5Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark Objective: Schizophrenia and/or antipsychotic drug use are associated with metabolic abnormalities; however, knowledge regarding metabolic status and physician’s monitoring of metabolic status at first schizophrenia diagnosis is sparse. We assessed the prevalence of monitoring for metabolic blood abnormalities and characterized the metabolic profiles in people with a first-time schizophrenia diagnosis. Methods: This is a population-based cross-sectional study including all adults born in Denmark after January 1, 1955, with their first schizophrenia diagnosis between 2000 and 2012 in the Central Denmark Region. Information on metabolic parameters was obtained from a clinical laboratory information system. Associations were calculated using Wilcoxon rank-sum tests, chi-square tests, logistic regression, and Spearman’s correlation coefficients. Results: A total of 2,452 people with a first-time schizophrenia diagnosis were identified, of whom 1,040 (42.4%) were monitored for metabolic abnormalities. Among those monitored, 58.4% had an abnormal lipid profile and 13.8% had an abnormal glucose profile. People who had previously filled prescription(s) for antipsychotic drugs were more likely to present an abnormal lipid measure (65.7% vs 46.8%, P<0.001) and abnormal glucose profile (16.4% vs 10.1%, P=0.01). Conclusion: Metabolic abnormalities are common at first schizophrenia diagnosis, particularly among those with previous antipsychotic prescription(s). Increased metabolic abnormalities already present in the early phase of schizophrenia emphasize the need for increased monitoring and management. Keywords: schizophrenia, metabolism, epidemiology, lipids, glucose
format	article
author	Horsdal HT Benros ME Köhler-Forsberg O Krogh J Gasse C
author_facet	Horsdal HT Benros ME Köhler-Forsberg O Krogh J Gasse C
author_sort	Horsdal HT
title	Metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study
title_short	Metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study
title_full	Metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study
title_fullStr	Metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study
title_full_unstemmed	Metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study
title_sort	metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/b2f43decd3394a1f9b117cb930f458fd
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_version_	1718402670960574464

Metabolic profile at first-time schizophrenia diagnosis: a population-based cross-sectional study

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